Population Pharmacokinetics of Flucloxacillin In Bone and Soft Tissue- Standard Dosing is Not Sufficient to Achieve Therapeutic Concentrations.
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DOI: 10.1007/s11095-022-03197-y
Abstract: PURPOSE Flucloxacillin is a β-lactam penicillin commonly used in the treatment of bone and soft tissue infections. In a recent porcine study, we found surprisingly low time for which the free concentration was maintained above… read more here.
Keywords: therapeutic concentrations; bone; bone soft; tissue ... See more keywords
High Doses of Drugs Extensively Metabolized by CYP3A4 Were Needed to Reach Therapeutic Concentrations in Two Patients Taking Inducers.
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DOI: 10.1016/j.rcp.2018.07.002
Abstract: INTRODUCTION In the last 20 years of clinical practice, the senior author has identified these 2 rare cases in which the patients needed extremely high doses of drugs metabolized by CYP3A4 to reach and maintain… read more here.
Keywords: doses drugs; high doses; therapeutic concentrations; day ... See more keywords