A Landscape of Therapeutic Cooperativity in KRAS Mutant Cancers Reveals Principles for Controlling Tumor Evolution.
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DOI: 10.1016/j.celrep.2017.07.006
Abstract: Combinatorial inhibition of effector and feedback pathways is a promising treatment strategy for KRAS mutant cancers. However, the particular pathways that should be targeted to optimize therapeutic responses are unclear. Using CRISPR/Cas9, we systematically mapped… read more here.
Keywords: mutant cancers; therapeutic cooperativity; landscape therapeutic; cancers reveals ... See more keywords