Therapeutic Development in COVID-19.
Sign Up to like & getrecommendations! Published in 2021 at "Advances in experimental medicine and biology"
DOI: 10.1007/978-3-030-63761-3_25
Abstract: Since the outbreak of coronavirus disease 2019 (COVID-19) caused by the SARS-CoV-2, the disease has spread rapidly worldwide and developed into a global pandemic, causing a significant impact on the global health system and economic… read more here.
Keywords: development covid; covid; biology; therapeutic development ... See more keywords
Linking Scattered Stem Cell-Based Data to Advance Therapeutic Development.
Sign Up to like & getrecommendations! Published in 2019 at "Trends in molecular medicine"
DOI: 10.1016/j.molmed.2018.10.008
Abstract: The biomedical field has witnessed remarkable advances in analytical tools and technologies that have expanded our understanding of healthy and diseased human tissue and, at the same time, enable extensive molecular characterization of living cells.… read more here.
Keywords: cell based; stem cell; therapeutic development;
A Coordinated Attack: Rett Syndrome Therapeutic Development.
Sign Up to like & getrecommendations! Published in 2019 at "Trends in pharmacological sciences"
DOI: 10.1016/j.tips.2019.02.007
Abstract: Rett syndrome (RTT) is a neurodevelopmental disorder caused by mutations in the Methyl CpG binding protein 2 (MeCP2) gene. This Science & Society article focuses on pharmacological strategies that attack RTT treatment from multiple angles,… read more here.
Keywords: coordinated attack; syndrome therapeutic; attack rett; rett syndrome ... See more keywords
Reactive chemistry for covalent probe and therapeutic development.
Sign Up to like & getrecommendations! Published in 2022 at "Trends in pharmacological sciences"
DOI: 10.1016/j.tips.2021.12.002
Abstract: Bioactive small molecules that form covalent bonds with a target protein are important tools for basic research and can be highly effective drugs. This review highlights reactive groups found in a collection of thiophilic and… read more here.
Keywords: chemistry; covalent probe; covalent; probe therapeutic ... See more keywords
Decoding pseudouridine: an emerging target for therapeutic development.
Sign Up to like & getrecommendations! Published in 2022 at "Trends in pharmacological sciences"
DOI: 10.1016/j.tips.2022.03.008
Abstract: Pseudouridine (Ψ) is the most abundant post-transcriptional RNA modification and is widespread in multiple RNA species. Ψ impacts various aspects of RNA biology, conferring distinct structural and functional properties to the RNA molecules that it… read more here.
Keywords: pseudouridine; emerging target; therapeutic development; decoding pseudouridine ... See more keywords
Multidimensional analysis and therapeutic development using patient iPSC–derived disease models of Wolfram syndrome
Sign Up to like & getrecommendations! Published in 2022 at "JCI Insight"
DOI: 10.1172/jci.insight.156549
Abstract: Wolfram syndrome is a rare genetic disorder largely caused by pathogenic variants in the WFS1 gene and manifested by diabetes mellitus, optic nerve atrophy, and progressive neurodegeneration. Recent genetic and clinical findings have revealed Wolfram… read more here.
Keywords: ipsc derived; therapeutic development; analysis; wfs1 1672c ... See more keywords
Therapeutic Development by Targeting the cGAS-STING Pathway in Autoimmune Disease and Cancer
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2021.779425
Abstract: DNA immune recognition regulation mediated by the cGAS-STING pathway plays an important role in immune functions. Under normal physiological conditions, cGAS can recognize and bind to invading pathogen DNA and activate the innate immune response.… read more here.
Keywords: targeting cgas; cancer; sting pathway; therapeutic development ... See more keywords
Editorial: Clinical Therapeutic Development Against Cancers Resistant to Targeted Therapies
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2021.816896
Abstract: Sydney Pharmacy School, Faculty of Medicine and Health, The University of Sydney, Sydney, NSW, Australia, Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, China, Zhejiang Provincial Key Laboratory… read more here.
Keywords: clinical therapeutic; cancers resistant; development cancers; therapeutic development ... See more keywords
COVID-19: Rehabilitation Needs, Therapeutic Development, and Impact on the Health System
Sign Up to like & getrecommendations! Published in 2023 at "Applied Sciences"
DOI: 10.3390/app13084872
Abstract: The COVID-19 pandemic has impacted the health of millions of people worldwide, with many survivors experiencing persistent symptoms and long-term disabilities [...] read more here.
Keywords: health; covid rehabilitation; therapeutic development; development impact ... See more keywords