Chemical screening in zebrafish for novel biological and therapeutic discovery.
Sign Up to like & getrecommendations! Published in 2017 at "Methods in cell biology"
DOI: 10.1016/bs.mcb.2016.10.004
Abstract: Zebrafish chemical screening allows for an in vivo assessment of small molecule modulation of biological processes. Compound toxicities, chemical alterations by metabolism, pharmacokinetic and pharmacodynamic properties, and modulation of cell niches can be studied with… read more here.
Keywords: therapeutic discovery; chemical screening; screening zebrafish; discovery chemical ... See more keywords
Targeting survivin for therapeutic discovery: past, present, and future promises.
Sign Up to like & getrecommendations! Published in 2017 at "Drug discovery today"
DOI: 10.1016/j.drudis.2017.05.009
Abstract: Survivin, the smallest member of the inhibitor of apoptosis protein (IAP) family, is overexpressed in cells of almost all cancers but not in most normal tissues in adults. Survivin expression is required for cancer cell… read more here.
Keywords: survivin therapeutic; discovery; targeting survivin; drug discovery ... See more keywords
'Channeling' therapeutic discovery for epileptic encephalopathy through iPSC technologies.
Sign Up to like & getrecommendations! Published in 2022 at "Trends in pharmacological sciences"
DOI: 10.1016/j.tips.2022.03.001
Abstract: Induced pluripotent stem cell (iPSC) and gene editing technologies have revolutionized the field of in vitro disease modeling, granting us access to disease-pertinent human cells of the central nervous system. These technologies are particularly well… read more here.
Keywords: therapeutic discovery; epileptic encephalopathy; discovery epileptic; encephalopathy ipsc ... See more keywords
Human Organ-on-a-Chip Microphysiological Systems to Model Musculoskeletal Pathologies and Accelerate Therapeutic Discovery
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Bioengineering and Biotechnology"
DOI: 10.3389/fbioe.2022.846230
Abstract: Human Microphysiological Systems (hMPS), otherwise known as organ- and tissue-on-a-chip models, are an emerging technology with the potential to replace in vivo animal studies with in vitro models that emulate human physiology at basic levels.… read more here.
Keywords: therapeutic discovery; musculoskeletal tissues; chip; microphysiological systems ... See more keywords
Highly Parallelized, Multicolor Optogenetic Recordings of Cellular Activity for Therapeutic Discovery Applications in Ion Channels and Disease-Associated Excitable Cells
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Molecular Neuroscience"
DOI: 10.3389/fnmol.2022.896320
Abstract: Optogenetic assays provide a flexible, scalable and information rich approach to probe compound effects for ion channel drug targets in both heterologous expression systems and associated disease relevant cell types. Despite the potential utility and… read more here.
Keywords: therapeutic discovery; parallelized multicolor; swarm; excitable cells ... See more keywords