Sub-therapeutic doses of fluvastatin and valsartan are more effective than therapeutic doses in providing beneficial cardiovascular pleiotropic effects in rats: A proof of concept study.
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DOI: 10.1016/j.vph.2017.09.005
Abstract: BACKGROUND Statins and sartans can, in therapeutic doses, induce pleiotropic cardiovascular effects. Similar has recently been shown also for sub-therapeutic doses. We thus explored and compared the cardiovascular pleiotropic efficacy of sub-therapeutic vs. therapeutic doses.… read more here.
Keywords: sub therapeutic; therapeutic doses; doses fluvastatin; fluvastatin valsartan ... See more keywords
Inhaled glucocorticoid-induced metabolome changes in asthma
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DOI: 10.1530/eje-21-0912
Abstract: Objective The aim of this study was toidentify dose-related systemic effects of inhaled glucocorticoids (GCs) on the global metabolome. Design and methods Metabolomics/lipidomic analysis from plasma was obtained from 54 subjects receiving weekly escalating doses… read more here.
Keywords: metabolome changes; inhaled glucocorticoid; induced metabolome; therapeutic doses ... See more keywords
Cost of treating peripheral neuropathic pain with pregabalin or gabapentin at therapeutic doses in routine practice.
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DOI: 10.2217/cer-2018-0008
Abstract: AIM To analyze the cost of peripheral neuropathic pain (PNP) treatment with pregabalin or gabapentin at therapeutic doses in routine clinical practice. METHODS Analysis of a retrospective, observational study of electronic medical records of patients… read more here.
Keywords: cost; practice; therapeutic doses; pregabalin gabapentin ... See more keywords
Effects of Therapeutic Doses of Celecoxib on Several Physiological Parameters of Cultured Human Osteoblasts
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DOI: 10.7150/ijms.37857
Abstract: Non-steroidal anti-inflammatory drugs (NSAIDs), including cyclooxygenase-2 (COX-2)-selective NSAIDs, are associated with adverse effects on bone tissue. These drugs are frequently the treatment of choice but are the least studied with respect to their repercussion on… read more here.
Keywords: therapeutic doses; cultured human; doses celecoxib; effect ... See more keywords