Therapeutic Drug Monitoring of Newer Antiepileptic Drugs: A Randomized Trial for Dosage Adjustment
Sign Up to like & getrecommendations! Published in 2019 at "Annals of Neurology"
DOI: 10.1002/ana.25641
Abstract: Therapeutic drug monitoring (TDM) of antiepileptic drugs (AEDs) is widely established for older generation AEDs, whereas there is limited evidence about newer AEDs. Our aim is to assess the benefit of TDM of newer generation… read more here.
Keywords: antiepileptic drugs; therapeutic drug; drug monitoring; monitoring newer ... See more keywords
Practical Recommendations for Therapeutic Drug Monitoring of Kinase Inhibitors in Oncology
Sign Up to like & getrecommendations! Published in 2017 at "Clinical Pharmacology and Therapeutics"
DOI: 10.1002/cpt.787
Abstract: Despite the fact that pharmacokinetic exposure of kinase inhibitors (KIs) is highly variable and clear relationships exist between exposure and treatment outcomes, fixed dosing is still standard practice. This review aims to summarize the available… read more here.
Keywords: kinase inhibitors; therapeutic drug; drug monitoring; oncology ... See more keywords
UPLC-MS/MS method for therapeutic drug monitoring of 10 antibiotics used in intensive care units.
Sign Up to like & getrecommendations! Published in 2018 at "Drug testing and analysis"
DOI: 10.1002/dta.2253
Abstract: A large variation in the levels of different ß-lactams and other antibiotics used in critically ill patients has been documented. The aim of this study is to establish and validate a fast, ultra-performance liquid chromatography-tandem… read more here.
Keywords: uplc method; antibiotics used; drug; therapeutic drug ... See more keywords
An online tool for information to women with epilepsy and therapeutic drug monitoring in pregnancy: Design and pilot study
Sign Up to like & getrecommendations! Published in 2021 at "Epilepsia Open"
DOI: 10.1002/epi4.12473
Abstract: Information to women with epilepsy on pregnancy‐related antiseizure medication (ASM) issues and reliable tools for therapeutic drug monitoring (TDM) are important aspects of epilepsy care. We aimed to develop and test an online tool for… read more here.
Keywords: information women; pregnancy; online tool; women epilepsy ... See more keywords
Therapeutic drug monitoring of perampanel in children diagnosed with epilepsy: Focus on influencing factors on the plasma concentration‐to‐dose ratio
Sign Up to like & getrecommendations! Published in 2022 at "Epilepsia Open"
DOI: 10.1002/epi4.12653
Abstract: This study aimed to investigate the efficacy and tolerability of perampanel (PER) therapy and to optimize a specific plasma reference range for PER in children. Another major aim was to evaluate the potential determinators of… read more here.
Keywords: monitoring perampanel; therapeutic drug; concentration; perampanel children ... See more keywords
Malic enzyme 2 as a potential therapeutic drug target for cancer
Sign Up to like & getrecommendations! Published in 2018 at "IUBMB Life"
DOI: 10.1002/iub.1930
Abstract: Reprogrammed metabolic profile is a biochemical fingerprint of cancerous cells, which represents one of the “hallmarks of cancer.” The aberrant expression pattern of enzymatic machineries orchestrates metabolic activities into a platform that ultimately promotes cellular… read more here.
Keywords: enzyme potential; malic enzyme; target; therapeutic drug ... See more keywords
Long-Acting Lipoglycopeptides Can Interfere With Vancomycin Therapeutic Drug Monitoring.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of clinical pharmacology"
DOI: 10.1002/jcph.1975
Abstract: Oritavancin and dalbavancin are long-acting lipoglycopeptides with activity against susceptible gram-positive bacteria, including methicillin-resistant Staphylococcus aureus. Though similar in structure to traditional glycopeptide antibiotics like vancomycin, these antibiotics have terminal half-lives greater than 10 days,… read more here.
Keywords: vancomycin; long acting; therapeutic drug; acting lipoglycopeptides ... See more keywords
Diagnostic Accuracy of Therapeutic Drug Monitoring During Tuberculosis Treatment
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Clinical Pharmacology"
DOI: 10.1002/jcph.2068
Abstract: Patients with tuberculosis (TB) coinfected with HIV are more likely to have low blood concentrations of the first‐line anti‐TB drugs (associated with poor outcomes). Therapeutic drug monitoring (TDM) is recommended for certain patient populations with… read more here.
Keywords: serum; accuracy; therapeutic drug; first line ... See more keywords
[Therapeutic drug monitoring in neuropsychopharmacology : Summary of the consensus guidelines 2017 of the TDM task force of the AGNP].
Sign Up to like & getrecommendations! Published in 2019 at "Der Nervenarzt"
DOI: 10.1007/s00115-018-0643-9
Abstract: Therapeutic drug monitoring (TDM) is the quantification and interpretation of drug concentrations in blood serum or plasma to optimize pharmacological therapy. TDM is an instrument with which the high interindividual variability of pharmacokinetics of patients… read more here.
Keywords: tdm task; drug; therapeutic drug; tdm ... See more keywords
Therapeutic drug monitoring of children and adolescents treated with aripiprazole: observational results from routine patient care
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Neural Transmission"
DOI: 10.1007/s00702-020-02253-4
Abstract: Although aripiprazole is one of the most used antipsychotics, knowledge about serum concentrations in children and adolescents is scarce and age-specific therapeutic ranges have not been established yet. Data of a routine therapeutic drug monitoring… read more here.
Keywords: serum concentrations; treated aripiprazole; therapeutic drug; children adolescents ... See more keywords
Therapeutic Drug Monitoring Strategies for Envarsus in De Novo Kidney Transplant Patients Using Population Modelling and Simulations
Sign Up to like & getrecommendations! Published in 2021 at "Advances in Therapy"
DOI: 10.1007/s12325-021-01905-5
Abstract: Tacrolimus, the cornerstone of transplantation immunosuppression, is a narrow therapeutic index drug with a low and highly variable bioavailability. Therapeutic drug monitoring based on trough level assessment is mandatory in order to target a personalised… read more here.
Keywords: therapeutic drug; model; novo kidney; drug monitoring ... See more keywords