Antiviral peptides as promising therapeutic drugs
Sign Up to like & getrecommendations! Published in 2019 at "Cellular and Molecular Life Sciences"
DOI: 10.1007/s00018-019-03138-w
Abstract: While scientific advances have led to large-scale production and widespread distribution of vaccines and antiviral drugs, viruses still remain a major cause of human diseases today. The ever-increasing reports of viral resistance and the emergence… read more here.
Keywords: antiviral peptides; therapeutic drugs; peptides promising; antimicrobial peptides ... See more keywords
Therapeutic drugs modulate ATP-Binding cassette transporter-mediated transport of amyloid beta(1-42) in brain microvascular endothelial cells.
Sign Up to like & getrecommendations! Published in 2020 at "European journal of pharmacology"
DOI: 10.1016/j.ejphar.2020.173009
Abstract: Deposition of amyloid-β peptide (Aβ(1-42)) is a hallmark of Alzheimer's disease. Clearance of Aβ(1-42), across the blood-brain barrier (BBB), is mediated by ATP-binding Cassette (ABC) efflux transporters. Many therapeutic drugs inhibit ABC transporters, but little… read more here.
Keywords: abcb1 abcc5; transport; abcc5 abcg2; endothelial cells ... See more keywords
Sub-ppt Mass Spectrometric Detection of Therapeutic Drugs in Complex Biological Matrixes Using Polystyrene-Microsphere-Coated Paper Spray.
Sign Up to like & getrecommendations! Published in 2017 at "Analytical chemistry"
DOI: 10.1021/acs.analchem.7b01296
Abstract: Polystyrene (PS) is a class of polymer materials that offers great potential for various applications. However, the applications of PS microspheres in paper spray mass spectrometry are largely underexplored. Herein we prepared a series of… read more here.
Keywords: spray; paper; coated paper; paper spray ... See more keywords
Bioinformatic Exploration of Hub Genes and Potential Therapeutic Drugs for Endothelial Dysfunction in Hypoxic Pulmonary Hypertension
Sign Up to like & getrecommendations! Published in 2022 at "Computational and Mathematical Methods in Medicine"
DOI: 10.1155/2022/3677532
Abstract: Hypoxic pulmonary hypertension (HPH) is a fatal chronic pulmonary circulatory disease, characterized by hypoxic pulmonary vascular constriction and remodeling. Studies performed to date have confirmed that endothelial dysfunction plays crucial roles in HPH, while the… read more here.
Keywords: hub genes; hub; hsa mir; hypoxic pulmonary ... See more keywords
A review on the clinical trials of repurposing therapeutic drugs, mechanisms and preventive measures against SARS-CoV-2
Sign Up to like & getrecommendations! Published in 2021 at "Drug Metabolism and Personalized Therapy"
DOI: 10.1515/dmpt-2020-0184
Abstract: Abstract Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is a highly transmittable pathogenic viral infection that causes a disease known as COVID-19. It is a pandemic and public health challenge ravaging the world today. Unfortunately, with… read more here.
Keywords: preventive measures; review clinical; clinical trials; trials repurposing ... See more keywords
Identification of Hub Diagnostic Biomarkers and Candidate Therapeutic Drugs in Heart Failure
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of General Medicine"
DOI: 10.2147/ijgm.s349235
Abstract: Purpose The objective of this study was to identify the potential regulatory mechanisms, diagnostic biomarkers, and therapeutic drugs for heart failure (HF). Methods Differentially expressed genes (DEGs) between HF and non-failing donors were screened from… read more here.
Keywords: hub genes; hub; therapeutic drugs; diagnostic biomarkers ... See more keywords
Integrated bioinformatics analysis for the screening of hub genes and therapeutic drugs in Hepatocellular carcinoma.
Sign Up to like & getrecommendations! Published in 2022 at "Current pharmaceutical biotechnology"
DOI: 10.2174/1389201023666220628113452
Abstract: BACKGROUND Liver cancer is a major medical problem because of its high morbidity and mortality. Hepatocellular carcinoma (HCC) is the most common type of liver cancer. At present, the mechanism of HCC is not clear,… read more here.
Keywords: hub genes; hub; hcc; therapeutic drugs ... See more keywords
Therapeutic Drugs in Bone Loss-Associated Disorders: Clinical Outcomes and Challenges.
Sign Up to like & getrecommendations! Published in 2017 at "Current drug targets"
DOI: 10.2174/1389450117666160709024547
Abstract: Current therapeutic drugs for the treatment of bone loss-associated disorders such as osteoporosis and metastatic bone disease have limited clinical outcomes, namely in terms of efficiency and sustainability. Given the ageing of population in developed… read more here.
Keywords: clinical outcomes; loss associated; loss; bone loss ... See more keywords
Diverse Roles of Mitochondria in Renal Injury from Environmental Toxicants and Therapeutic Drugs
Sign Up to like & getrecommendations! Published in 2021 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms22084172
Abstract: Mitochondria are well-known to function as the primary sites of ATP synthesis in most mammalian cells, including the renal proximal tubule. Other functions have also been associated with different mitochondrial activities, including the regulation of… read more here.
Keywords: therapeutic drugs; mitochondria renal; renal injury; diverse roles ... See more keywords
Reptiles as Promising Sources of Medicinal Natural Products for Cancer Therapeutic Drugs
Sign Up to like & getrecommendations! Published in 2022 at "Pharmaceutics"
DOI: 10.3390/pharmaceutics14040874
Abstract: Natural products have historically played an important role as a source of therapeutic drugs for various diseases, and the development of medicinal natural products is still a field with high potential. Although diverse drugs have… read more here.
Keywords: promising sources; natural products; medicinal natural; cancer ... See more keywords
A Source of Novel Therapeutic Drugs- Marine Actinomycetes
Sign Up to like & getrecommendations! Published in 2017 at "Research Journal of Pharmacy and Technology"
DOI: 10.5958/0974-360x.2017.00652.7
Abstract: Marine resource has a wide range of products useful for mankind. They are not only rich in fisheries as well the entire oceanic world leads to produce variety of brand new products such as cosmetics,… read more here.
Keywords: source novel; drugs marine; marine actinomycetes; therapeutic drugs ... See more keywords