Concerns Regarding Therapeutic Implications of Very Low‐Level Dystrophin
Sign Up to like & getrecommendations! Published in 2021 at "Annals of Neurology"
DOI: 10.1002/ana.26097
Abstract: chain (sNfL) observed by Chung et al in their cohort with bacterial pneumonia. Important in our view is the observation that neuronal damage occurs in the course of both COVID-19 and sepsisassociated encephalopathy (ie, also… read more here.
Keywords: regarding therapeutic; therapeutic implications; level dystrophin; concerns regarding ... See more keywords
Prognostic and therapeutic implications of NHERF1 expression and regulation in colorectal cancer
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Surgical Oncology"
DOI: 10.1002/jso.25805
Abstract: Na+/H+ exchanger regulatory factor 1 (NHERF1) has been implicated in the tumorigenesis of several cancer types and is a potential therapeutic target. The current study evaluated the relationship between NHERF1 expression and clinical outcome in… read more here.
Keywords: colorectal cancer; therapeutic implications; nherf1 expression; cancer ... See more keywords
Therapeutic implications of endoplasmic reticulum stress gene CCL3 in cervical squamous cell carcinoma
Sign Up to like & getrecommendations! Published in 2025 at "Cell Biology and Toxicology"
DOI: 10.1007/s10565-024-09949-3
Abstract: This study investigated ERS-related gene expressions in CESC, identifying two molecular subtypes, P1 and P2, and constructing a precise prognostic model based on these subtypes. TCGA's whole-genome expression profiles were used to recognize these subtypes… read more here.
Keywords: ccl3; endoplasmic reticulum; cell; gene ... See more keywords
Interaction Between Primary Hyperlipidemias and Type 2 Diabetes: Therapeutic Implications
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DOI: 10.1007/s13300-024-01626-2
Abstract: There is a gap of knowledge about the clinical and pathophysiological implications resulting from the interaction between primary hyperlipidemias and type 2 diabetes (T2D). Most of the existing evidence comes from sub-analyses of cohorts; scant… read more here.
Keywords: hyperlipidemias type; type diabetes; primary hyperlipidemias; diabetes therapeutic ... See more keywords
Autoimmunity in vitiligo: Therapeutic implications and opportunities.
Sign Up to like & getrecommendations! Published in 2021 at "Autoimmunity reviews"
DOI: 10.1016/j.autrev.2021.102932
Abstract: Vitiligo is an acquired chronic pigmentary disorder affecting the melanocytes, mainly in the skin and mucosae. It occurs due to the dynamic interaction between genetic and environmental factors leading to autoimmune destruction of melanocytes. Defects… read more here.
Keywords: vitiligo; implications opportunities; vitiligo therapeutic; therapeutic implications ... See more keywords
Therapeutic implications of nanomedicine for ocular drug delivery.
Sign Up to like & getrecommendations! Published in 2019 at "Drug discovery today"
DOI: 10.1016/j.drudis.2019.05.006
Abstract: Delivering therapeutics to the eye is challenging on multiple levels: rapid clearance of eyedrops from the ocular surface requires frequent instillation, which is difficult for patients; transport of drugs across the blood-retinal barrier when drugs… read more here.
Keywords: drug delivery; therapeutic implications; drug; implications nanomedicine ... See more keywords
Development and Therapeutic Implications of Tyrosine Kinase 2 Inhibitors.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.2c01800
Abstract: Janus kinases (JAKs) are central components in cytokine signaling pathways. A number of small molecule JAK inhibitors have been approved to treat a wide range of inflammatory and autoimmune diseases. Due to safety concerns of… read more here.
Keywords: kinase; tyk2 inhibitors; tyrosine kinase; therapeutic implications ... See more keywords
NADPH homeostasis in cancer: functions, mechanisms and therapeutic implications
Sign Up to like & getrecommendations! Published in 2020 at "Signal Transduction and Targeted Therapy"
DOI: 10.1038/s41392-020-00326-0
Abstract: Nicotinamide adenine dinucleotide phosphate (NADPH) is an essential electron donor in all organisms, and provides the reducing power for anabolic reactions and redox balance. NADPH homeostasis is regulated by varied signaling pathways and several metabolic… read more here.
Keywords: nadph homeostasis; therapeutic implications; homeostasis cancer; cancer cells ... See more keywords
DUBs in Alzheimer’s disease: mechanisms and therapeutic implications
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DOI: 10.1038/s41420-024-02237-3
Abstract: Alzheimer’s disease (AD) is a prevalent neurodegenerative disorder characterized by the accumulation of amyloid β protein (Aβ) and the hyper-phosphorylation of the microtubule-associated protein Tau. The ubiquitin-proteasome system (UPS) plays a pivotal role in determining… read more here.
Keywords: disease mechanisms; alzheimer disease; disease; mechanisms therapeutic ... See more keywords
Biological and therapeutic implications of a unique subtype of NPM1 mutated AML
Sign Up to like & getrecommendations! Published in 2021 at "Nature Communications"
DOI: 10.1038/s41467-021-21233-0
Abstract: In acute myeloid leukemia (AML), molecular heterogeneity across patients constitutes a major challenge for prognosis and therapy. AML with NPM1 mutation is a distinct genetic entity in the revised World Health Organization classification. However, differing… read more here.
Keywords: biological therapeutic; therapeutic implications; mutated aml; drug ... See more keywords
The emerging role of microRNAs in bone remodeling and its therapeutic implications for osteoporosis
Sign Up to like & getrecommendations! Published in 2018 at "Bioscience Reports"
DOI: 10.1042/bsr20180453
Abstract: Osteoporosis, a common and multifactorial disease, is influenced by genetic factors and environments. However, the pathogenesis of osteoporosis has not been fully elucidated yet. Recently, emerging evidence suggests that epigenetic modifications may be the underlying… read more here.
Keywords: therapeutic implications; implications osteoporosis; role; bone remodeling ... See more keywords