Concerns Regarding Therapeutic Implications of Very Low‐Level Dystrophin
Sign Up to like & getrecommendations! Published in 2021 at "Annals of Neurology"
DOI: 10.1002/ana.26097
Abstract: chain (sNfL) observed by Chung et al in their cohort with bacterial pneumonia. Important in our view is the observation that neuronal damage occurs in the course of both COVID-19 and sepsisassociated encephalopathy (ie, also… read more here.
Keywords: regarding therapeutic; therapeutic implications; level dystrophin; concerns regarding ... See more keywords
Prognostic and therapeutic implications of NHERF1 expression and regulation in colorectal cancer
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Surgical Oncology"
DOI: 10.1002/jso.25805
Abstract: Na+/H+ exchanger regulatory factor 1 (NHERF1) has been implicated in the tumorigenesis of several cancer types and is a potential therapeutic target. The current study evaluated the relationship between NHERF1 expression and clinical outcome in… read more here.
Keywords: colorectal cancer; therapeutic implications; nherf1 expression; cancer ... See more keywords
Autoimmunity in vitiligo: Therapeutic implications and opportunities.
Sign Up to like & getrecommendations! Published in 2021 at "Autoimmunity reviews"
DOI: 10.1016/j.autrev.2021.102932
Abstract: Vitiligo is an acquired chronic pigmentary disorder affecting the melanocytes, mainly in the skin and mucosae. It occurs due to the dynamic interaction between genetic and environmental factors leading to autoimmune destruction of melanocytes. Defects… read more here.
Keywords: vitiligo; implications opportunities; vitiligo therapeutic; therapeutic implications ... See more keywords
Therapeutic implications of nanomedicine for ocular drug delivery.
Sign Up to like & getrecommendations! Published in 2019 at "Drug discovery today"
DOI: 10.1016/j.drudis.2019.05.006
Abstract: Delivering therapeutics to the eye is challenging on multiple levels: rapid clearance of eyedrops from the ocular surface requires frequent instillation, which is difficult for patients; transport of drugs across the blood-retinal barrier when drugs… read more here.
Keywords: drug delivery; therapeutic implications; drug; implications nanomedicine ... See more keywords
Development and Therapeutic Implications of Tyrosine Kinase 2 Inhibitors.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.2c01800
Abstract: Janus kinases (JAKs) are central components in cytokine signaling pathways. A number of small molecule JAK inhibitors have been approved to treat a wide range of inflammatory and autoimmune diseases. Due to safety concerns of… read more here.
Keywords: kinase; tyk2 inhibitors; tyrosine kinase; therapeutic implications ... See more keywords
NADPH homeostasis in cancer: functions, mechanisms and therapeutic implications
Sign Up to like & getrecommendations! Published in 2020 at "Signal Transduction and Targeted Therapy"
DOI: 10.1038/s41392-020-00326-0
Abstract: Nicotinamide adenine dinucleotide phosphate (NADPH) is an essential electron donor in all organisms, and provides the reducing power for anabolic reactions and redox balance. NADPH homeostasis is regulated by varied signaling pathways and several metabolic… read more here.
Keywords: nadph homeostasis; therapeutic implications; homeostasis cancer; cancer cells ... See more keywords
Biological and therapeutic implications of a unique subtype of NPM1 mutated AML
Sign Up to like & getrecommendations! Published in 2021 at "Nature Communications"
DOI: 10.1038/s41467-021-21233-0
Abstract: In acute myeloid leukemia (AML), molecular heterogeneity across patients constitutes a major challenge for prognosis and therapy. AML with NPM1 mutation is a distinct genetic entity in the revised World Health Organization classification. However, differing… read more here.
Keywords: biological therapeutic; therapeutic implications; mutated aml; drug ... See more keywords
The emerging role of microRNAs in bone remodeling and its therapeutic implications for osteoporosis
Sign Up to like & getrecommendations! Published in 2018 at "Bioscience Reports"
DOI: 10.1042/bsr20180453
Abstract: Osteoporosis, a common and multifactorial disease, is influenced by genetic factors and environments. However, the pathogenesis of osteoporosis has not been fully elucidated yet. Recently, emerging evidence suggests that epigenetic modifications may be the underlying… read more here.
Keywords: therapeutic implications; implications osteoporosis; role; bone remodeling ... See more keywords
Interaction between the apelinergic system and ACE2 in the cardiovascular system: therapeutic implications.
Sign Up to like & getrecommendations! Published in 2020 at "Clinical science"
DOI: 10.1042/cs20200479
Abstract: The apelinergic system is widely expressed and acts through autocrine and paracrine signaling to exert protective effects, including vasodilatory, metabolic, and inotropic effects on the cardiovascular (CV) system. The apelin pathway's dominant physiological role has… read more here.
Keywords: system; therapeutic implications; apelin peptides; interaction ... See more keywords
Bouveret's Syndrome - Case Series with Therapeutic Implications.
Sign Up to like & getrecommendations! Published in 2020 at "Zeitschrift fur Gastroenterologie"
DOI: 10.1055/a-1113-7966
Abstract: Bouveret's syndrome is a rare complication resulting from gallstone disease. Both surgical and endoscopical procedures are performed, with the disease to be seen as strictly interdisciplinary. There are no well-established recommendations for this condition. In… read more here.
Keywords: bouveret syndrome; therapeutic implications; case series; syndrome case ... See more keywords
Novel and emerging targets for cholangiocarcinoma progression: therapeutic implications
Sign Up to like & getrecommendations! Published in 2022 at "Expert Opinion on Therapeutic Targets"
DOI: 10.1080/14728222.2022.2029412
Abstract: ABSTRACT Introduction Cholangiocarcinoma (CCA) is a heterogeneous group of aggressive biliary malignancies. While surgery and liver transplantation are the only potentially curative modalities for early-stage disease, limited options are available for most patients with incurable-stage… read more here.
Keywords: novel emerging; targets cholangiocarcinoma; cholangiocarcinoma progression; progression therapeutic ... See more keywords