Therapeutic index of lymphadenectomy among patients with pancreatic neuroendocrine tumors: A multi‐institutional analysis
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Surgical Oncology"
DOI: 10.1002/jso.25689
Abstract: The benefit derived from lymph node dissection (LND) in patients with pancreatic neuroendocrine tumors (pNETs) based on clinicopathological characteristics remains unclear. read more here.
Keywords: lymphadenectomy among; pancreatic neuroendocrine; index lymphadenectomy; neuroendocrine tumors ... See more keywords
Vascular Derived ECM Improves Therapeutic Index of BMP-2 and Drives Vascularized Bone Regeneration.
Sign Up to like & getrecommendations! Published in 2022 at "Small"
DOI: 10.1002/smll.202107991
Abstract: Vascularized osteogenesis is essential for successful bone regeneration, yet its realization during large size bone defect healing remains challenging due to the difficulty to couple multiple biological processes. Herein, harnessing the intrinsic angiogenic potential of… read more here.
Keywords: vascular derived; bone; bone regeneration; therapeutic index ... See more keywords
Study on the therapeutic index and synergistic effect of Chitosan-zinc oxide nanomicellar composites for drug-resistant bacterial biofilm inhibition.
Sign Up to like & getrecommendations! Published in 2019 at "International journal of pharmaceutics"
DOI: 10.1016/j.ijpharm.2019.05.003
Abstract: The synergistic effectiveness of chitosan with zinc oxide nanomicelles (CZNPs) on broad spectrum of multidrug resistance (MDR) was previously evidenced in our labs, requiring elucidation of the therapeutic index (TI) for safe in vivo use.… read more here.
Keywords: chitosan zinc; zinc oxide; micellar cznps; biofilm ... See more keywords
Characterisation of mexiletine’s translational therapeutic index for suppression of ischaemia-induced ventricular fibrillation in the rat isolated heart
Sign Up to like & getrecommendations! Published in 2020 at "Scientific Reports"
DOI: 10.1038/s41598-020-65190-y
Abstract: The ‘translational therapeutic index’ (TTI) is a drug’s ratio of nonclinical threshold dose (or concentration) for significant benefit versus threshold for adversity. In early nonclinical research, discovery and safety studies are normally undertaken separately. Our… read more here.
Keywords: index; translational therapeutic; ischaemia induced; mexiletine ... See more keywords
Improved therapeutic index of an acidic pH-selective antibody
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DOI: 10.1080/19420862.2021.2024642
Abstract: ABSTRACT Although therapeutically efficacious, ipilimumab can exhibit dose-limiting toxicity that prevents maximal efficacious clinical outcomes and can lead to discontinuation of treatment. We hypothesized that an acidic pH-selective ipilimumab (pH Ipi), which preferentially and reversibly… read more here.
Keywords: selective antibody; therapeutic index; improved therapeutic; acidic selective ... See more keywords
Enzymatic glycan remodeling–metal free click (GlycoConnect™) provides homogenous antibody-drug conjugates with improved stability and therapeutic index without sequence engineering
Sign Up to like & getrecommendations! Published in 2022 at "mAbs"
DOI: 10.1080/19420862.2022.2078466
Abstract: ABSTRACT Antibody-drug conjugates (ADCs) are increasingly powerful medicines for targeted cancer therapy. Inspired by the trend to further improve their therapeutic index by generation of homogenous ADCs, we report here how the clinical-stage GlycoConnect™ technology… read more here.
Keywords: metal free; drug conjugates; therapeutic index; free click ... See more keywords
Abstract 1521: Unlocking the therapeutic index of highly potent site-specific ADCs in solid tumors
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-1521
Abstract: CD276 (B7-H3) is a transmembrane protein of the B7 family, which includes many prominent immune checkpoint targets, and is expected to play a role in T-cell stimulation, tumor-infiltration, as well as other tumorigenic functions with… read more here.
Keywords: adcs solid; therapeutic index; solid tumors; adcs ... See more keywords
Abstract 1525: A novel platform for protein engineering and modification to expand the therapeutic index of anti-tumor therapeutics
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-1525
Abstract: Purpose: A key challenge in cancer drug development is optimizing the therapeutic index (TI), a measure of a treatment’s antitumor efficacy and its toxicity, such that the agent is effective in targeting the tumor with… read more here.
Keywords: novel platform; therapeutic index; tumor; engineering ... See more keywords
Tumor Targeted Nanoparticles Improve Therapeutic Index of BCL2 and MCL1 dual inhibition.
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DOI: 10.1182/blood.2020008017
Abstract: Cancer and normal cells utilize multiple anti-apoptotic BCL2 proteins to prevent cell death. Therapeutic targeting of multiple BCL2 family proteins enhances tumor killing, but is also associated with increased systemic toxicity. Here, we demonstrate that… read more here.
Keywords: nanoparticles improve; targeted nanoparticles; improve therapeutic; therapeutic index ... See more keywords
Comparative therapeutic index, lethal time and safety margin of various toxicants and snake antivenoms using newly derived and old formulas
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DOI: 10.1186/s13104-020-05134-x
Abstract: Objective The assessment of clinical efficacy and toxicity is very important in pharmacology and toxicology. The effects of psychostimulants (e.g. amphetamine), psychotomimetics (e.g. Cannabis sativus) and snake antivenoms are sometimes unpredictable even at lower doses,… read more here.
Keywords: safety margin; therapeutic index; safety; time ... See more keywords
Meeting Regulatory Requirements for Drugs with a Narrow Therapeutic Index: Bioequivalence Studies of Generic Once-Daily Tacrolimus
Sign Up to like & getrecommendations! Published in 2020 at "Drug, Healthcare and Patient Safety"
DOI: 10.2147/dhps.s256455
Abstract: Abstract Despite growing clinical confidence in generics and their potential to reduce long-term healthcare costs, the transplant community have had real concerns about the use of generic immunosuppressants. One such immunosuppressant is tacrolimus, a cornerstone… read more here.
Keywords: generic daily; therapeutic index; narrow therapeutic; tacrolimus ... See more keywords