Therapeutic Inhibition of Complement: Well Worth the Risk.
Sign Up to like & getrecommendations! Published in 2017 at "Trends in pharmacological sciences"
DOI: 10.1016/j.tips.2017.03.009
Abstract: Complement is an integral part of the immune system and protects against infection. Complement-mediated immunopathology in many autoimmune diseases and syndromes has led to the therapeutic targeting of complement and to questions around the safety… read more here.
Keywords: therapeutic inhibition; complement well; inhibition; complement ... See more keywords
Progress in the therapeutic inhibition of Cdc42 signalling
Sign Up to like & getrecommendations! Published in 2021 at "Biochemical Society Transactions"
DOI: 10.1042/bst20210112
Abstract: Cdc42 is a member of the Rho family of small GTPases and a key regulator of the actin cytoskeleton, controlling cell motility, polarity and cell cycle progression. It signals downstream of the master regulator Ras… read more here.
Keywords: cdc42; therapeutic inhibition; cell; progress therapeutic ... See more keywords
CBMT-38. THERAPEUTIC INHIBITION OF THE SPLICEOSOME IN GLIOBLASTOMA: CHANGES FORM MINOR TO MAJOR
Sign Up to like & getrecommendations! Published in 2019 at "Neuro-Oncology"
DOI: 10.1093/neuonc/noz175.160
Abstract: Chemical or genetic perturbation of the spliceosome function may represent a therapeutic opportunity for Glioblastoma multiforme (GBM) and other cancers. We and others have shown that oncogenic MYC activity causes spliceosome vulnerability and leads to… read more here.
Keywords: therapeutic inhibition; glioblastoma; inhibition spliceosome; cbmt therapeutic ... See more keywords
Therapeutic inhibition of miR-802 protects against obesity through AMPK-mediated regulation of hepatic lipid metabolism
Sign Up to like & getrecommendations! Published in 2021 at "Theranostics"
DOI: 10.7150/thno.49354
Abstract: Background: The host-parasite relationship is based on subtle interplay between parasite survival strategies and host defense mechanisms. It is well known that helminth infection, which afflicts more than one billion people globally, correlates with a… read more here.
Keywords: hepatic lipid; therapeutic inhibition; metabolism; mir 802 ... See more keywords