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Published in 2018 at "Journal of the American College of Cardiology"
DOI: 10.1016/j.jacc.2018.08.052
Abstract: Lingguizhugan decoction (LGZGD), a well-known traditional Chinese medicine (TCM) formula has been widely using in modern clinical practice to treat various cardiovascular disease, especially in chronic heart failure (CHF). However, the underlying therapeutic mechanism is not…
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Keywords:
therapeutic mechanism;
heart failure;
pharmacology;
lingguizhugan decoction ... See more keywords
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Published in 2021 at "Neurochemistry International"
DOI: 10.1016/j.neuint.2021.105044
Abstract: Posttraumatic stress disorder (PTSD) is a devastating medical illness, for which currently available pharmacotherapies have poor efficacy. Accumulating evidence from clinical and preclinical animal investigations supports that ketamine exhibits a rapid and persistent effect against…
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Keywords:
mechanism;
therapeutic mechanism;
ketamine;
mechanism ketamine ... See more keywords
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Published in 2019 at "Cold Spring Harbor symposia on quantitative biology"
DOI: 10.1101/sqb.2018.83.038174
Abstract: Dravet syndrome is an infantile epileptic encephalopathy primarily caused by loss-of-function variants of the gene SCN1A Standard treatment regimens have very limited efficacy to combat the life-threatening seizures in Dravet syndrome or the behavioral-cognitive comorbidities…
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Keywords:
mechanism;
model dravet;
therapeutic mechanism;
cellular model ... See more keywords
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Published in 2022 at "Journal of Cellular and Molecular Medicine"
DOI: 10.1111/jcmm.17568
Abstract: Our previous studies illustrated that 2% H2 inhalation can protect against sepsis‐associated encephalopathy (SAE) which is characterized by high mortality and has no effective treatment. To investigate the underlying role of protein phosphorylation in SAE…
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Keywords:
phosphorylation mediated;
brain;
phosphorylation;
signalling pathway ... See more keywords
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Published in 2022 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2022.1031051
Abstract: Traditional Chinese Medicine (TCM) is extensively utilized in clinical practice due to its therapeutic and preventative treatments for various diseases. With the development of high-throughput sequencing and systems biology, TCM research was transformed from traditional…
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Keywords:
multi omics;
medicine;
tcm;
therapeutic mechanism ... See more keywords
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Published in 2022 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2022.950749
Abstract: Curcuma aromatica Salisb. rhizome (CASR) has multifunctional characteristics worldwide and a long history of use as a botanical drug with. Currently, it is often used clinically to treat coronary heart disease (CHD) caused by blood…
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Keywords:
curcuma aromatica;
pharmacology;
casr;
chd ... See more keywords
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Published in 2022 at "Frontiers in Psychiatry"
DOI: 10.3389/fpsyt.2022.834425
Abstract: The lifetime prevalence of depression is reported to be >10%, and it is an important illness that causes various disabilities over a long period of life. Neuroinflammation process is often reported to be closely linked…
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Keywords:
magnetic stimulation;
depression;
repetitive transcranial;
transcranial magnetic ... See more keywords