Cartography of SARS‐CoV‐2 variants based on the susceptibility to therapeutic monoclonal antibodies
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Medical Virology"
DOI: 10.1002/jmv.28275
Abstract: A comprehensive picture of a phenotypic relationship among severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) variants has been poorly studied. Here, this study presents cartography showing how the wild‐type strain of SARS‐CoV‐2 and 14 variants… read more here.
Keywords: cov variants; therapeutic monoclonal; susceptibility therapeutic; cartography ... See more keywords
A Cell-Based Reporter Assay Measuring the Activation of Fc Gamma Receptors Induced by Therapeutic Monoclonal Antibodies.
Sign Up to like & getrecommendations! Published in 2019 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-8958-4_21
Abstract: Fc gamma receptors (FcγRs) are expressed on the surface of various immune cells, and the interactions between FcγRs and the Fc region of immunoglobulin G are involved in the activation of immune cells by antigen-bound… read more here.
Keywords: monoclonal antibodies; therapeutic monoclonal; cell based; activation ... See more keywords
Tight Interplay Between Therapeutic Monoclonal Antibodies and the Tumour Microenvironment in Cancer Therapy.
Sign Up to like & getrecommendations! Published in 2020 at "Advances in experimental medicine and biology"
DOI: 10.1007/978-3-030-50224-9_9
Abstract: Therapeutic monoclonal antibodies (mAb) have changed the landscape of cancer therapy. With advances in the understanding of tumour biology and its microenvironment, different categories of mAbs have been developed; a first category is directed against… read more here.
Keywords: monoclonal antibodies; therapeutic monoclonal; biology; tumour microenvironment ... See more keywords
Development of a Targeted Mass-Spectrometry Serum Assay To Quantify M-Protein in the Presence of Therapeutic Monoclonal Antibodies.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of proteome research"
DOI: 10.1021/acs.jproteome.7b00890
Abstract: M-protein diagnostics can be compromised for patients receiving therapeutic monoclonal antibodies as treatment in multiple myeloma. Conventional techniques are often not able to distinguish between M-proteins and therapeutic monoclonal antibodies administered to the patient. This… read more here.
Keywords: protein; therapeutic monoclonal; monoclonal antibodies; mass spectrometry ... See more keywords
Developing therapeutic monoclonal antibodies at pandemic pace
Sign Up to like & getrecommendations! Published in 2020 at "Nature Biotechnology"
DOI: 10.1038/s41587-020-0512-5
Abstract: The time from discovery to proof-of-concept trials could be reduced to 5–6 months from a traditional timeline of 10–12 months. read more here.
Keywords: pandemic pace; monoclonal antibodies; therapeutic monoclonal; antibodies pandemic ... See more keywords
Therapeutic monoclonal antibodies for COVID-19 management: an update
Sign Up to like & getrecommendations! Published in 2022 at "Expert Opinion on Biological Therapy"
DOI: 10.1080/14712598.2022.2078160
Abstract: ABSTRACT Background The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has affected more than 529 million people, and today the world is facing different mutant strains of the virus, leading to increased morbidity rates, fatality… read more here.
Keywords: covid management; antibodies covid; therapeutic monoclonal; therapy ... See more keywords
The challenges with developing therapeutic monoclonal antibodies for pandemic application
Sign Up to like & getrecommendations! Published in 2021 at "Expert Opinion on Drug Discovery"
DOI: 10.1080/17460441.2021.1976141
Abstract: Throughout history, pandemics like the Black Death or the Spanish Flue have periodically wiped out large parts of populations. Today, history repeats itself with the on-going SARSCoV-2 pandemic, which manifests that pandemics still hold the… read more here.
Keywords: challenges developing; therapeutic monoclonal; pandemic application; developing therapeutic ... See more keywords
Integrated flow-through purification for therapeutic monoclonal antibodies processing
Sign Up to like & getrecommendations! Published in 2018 at "mAbs"
DOI: 10.1080/19420862.2017.1417717
Abstract: ABSTRACT An integrated all flow-through technology platform for the purification of therapeutic monoclonal antibodies (mAb), consisting of activated carbon and flow-through cation and anion exchange chromatography steps, can replace a conventional chromatography platform. This new… read more here.
Keywords: flow purification; monoclonal antibodies; therapeutic monoclonal; purification ... See more keywords
Interference of Therapeutic Monoclonal Antibodies With Routine Serum Protein Electrophoresis and Immunofixation in Patients With Myeloma: Frequency and Duration of Detection of Daratumumab and Elotuzumab
Sign Up to like & getrecommendations! Published in 2018 at "American Journal of Clinical Pathology"
DOI: 10.1093/ajcp/aqy037
Abstract: Objectives We investigated the frequency and pattern of detection of therapeutic monoclonal antibodies (t-mAbs) daratumumab and elotuzumab by routine serum protein electrophoresis (SPE) and immunofixation (IF) in treated patients with myeloma. Methods Detection of t-mAb… read more here.
Keywords: protein; detection; monoclonal antibodies; therapeutic monoclonal ... See more keywords
Therapeutic Monoclonal Antibody Interference in Monoclonal Gammopathy Monitoring: a Denosumab Experience.
Sign Up to like & getrecommendations! Published in 2022 at "Laboratory medicine"
DOI: 10.1093/labmed/lmac129
Abstract: A 73-year-old woman was diagnosed with a lambda light chain myeloma. A follow-up immunofixation electrophoresis showed a monoclonal immunoglobulin (Ig)G kappa in addition to the regular lambda band. A monoclonal antibody therapy interference was suspected… read more here.
Keywords: denosumab; monoclonal antibody; therapeutic monoclonal; interference ... See more keywords
Advances and challenges in therapeutic monoclonal antibodies drug development
Sign Up to like & getrecommendations! Published in 2018 at "Brazilian Journal of Pharmaceutical Sciences"
DOI: 10.1590/s2175-97902018000001007
Abstract: The use of serum containing polyclonal antibodies from animals immunized with toxins marked the beginning of the application of antibody-based therapy in late nineteenth century. Advances in basic research led to the development of the… read more here.
Keywords: monoclonal antibodies; therapeutic monoclonal; drug; challenges therapeutic ... See more keywords