Chemical Development of Therapeutic Oligonucleotides.
Sign Up to like & getrecommendations! Published in 2019 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-9670-4_1
Abstract: The development of several different chemical modifications of nucleic acids, with improved base-pairing affinity and specificity as well as increased resistance against nucleases, has been described. These new chemistries have allowed the synthesis of different… read more here.
Keywords: development therapeutic; chemical development; biology; development ... See more keywords
In Vitro Assessment of the Hepatotoxicity Potential of Therapeutic Oligonucleotides.
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DOI: 10.1007/978-1-4939-9670-4_15
Abstract: The mechanisms of antisense oligonucleotide-induced liver toxicity are still poorly understood. Assessment of the hepatic safety profile is currently mostly investigated directly in rodent studies. A predictive preclinical in vitro model that is capturing liver… read more here.
Keywords: hepatotoxicity potential; vitro assessment; assessment hepatotoxicity; biology ... See more keywords
A perspective on RNA interference-based therapeutics for metabolic liver diseases
Sign Up to like & getrecommendations! Published in 2021 at "Expert Opinion on Investigational Drugs"
DOI: 10.1080/13543784.2021.1879792
Abstract: ABSTRACT Introduction: Therapeutic oligonucleotides have emerged as a promising new class of drug that could silence undruggable targets; they can potentially treat metabolic liver diseases such as nonalcoholic fatty liver disease (NAFLD), hereditary hemochromatosis and… read more here.
Keywords: liver diseases; rna interference; metabolic liver; perspective rna ... See more keywords
Hyaluronan-based delivery of therapeutic oligonucleotides for treatment of human diseases
Sign Up to like & getrecommendations! Published in 2019 at "Expert Opinion on Drug Delivery"
DOI: 10.1080/17425247.2019.1617693
Abstract: ABSTRACT Introduction: Oligonucleotide therapeutics such as antisense oligonucleotides and siRNA requires chemical modifications and nano-sized carriers to circumvent stability problems in vivo, to reach target tissues, and to overcome tissue and cellular barriers. Hyaluronic acid… read more here.
Keywords: delivery; oligonucleotide therapeutics; based delivery; hyaluronan based ... See more keywords
Measuring DNA hybridization using fluorescent DNA-stabilized silver clusters to investigate mismatch effects on therapeutic oligonucleotides
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Nanobiotechnology"
DOI: 10.1186/s12951-018-0361-2
Abstract: BackgroundShort nucleic acid oligomers have found a wide range of applications in experimental physics, biology and medicine, and show potential for the treatment of acquired and genetic diseases. These applications rely heavily on the predictability… read more here.
Keywords: fluorescent dna; dna; hybridization; therapeutic oligonucleotides ... See more keywords
Trioleyl Pyridinium, a Cationic Transfection Agent for the Lipofection of Therapeutic Oligonucleotides into Mammalian Cells
Sign Up to like & getrecommendations! Published in 2023 at "Pharmaceutics"
DOI: 10.3390/pharmaceutics15020420
Abstract: Background: One of the most significant limitations that therapeutic oligonucleotides present is the development of specific and efficient delivery vectors for the internalization of nucleic acids into cells. Therefore, there is a need for the… read more here.
Keywords: dna; oligonucleotides mammalian; agent; mammalian cells ... See more keywords