Lymphopenia in COVID‐19: Therapeutic opportunities
Sign Up to like & getrecommendations! Published in 2020 at "Cell Biology International"
DOI: 10.1002/cbin.11403
Abstract: Abstract Severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) is uncontrollably spread all over the world. The host immune responses strongly try to confront it with all the potential cells and cytokines. With chronically condition of… read more here.
Keywords: therapeutic opportunities; covid therapeutic; lymphopenia covid;
Regen med therapeutic opportunities for fighting COVID‐19
Sign Up to like & getrecommendations! Published in 2020 at "Stem Cells Translational Medicine"
DOI: 10.1002/sctm.20-0245
Abstract: This perspective from a Regenerative Medicine Manufacturing Society working group highlights regenerative medicine therapeutic opportunities for fighting COVID‐19. This article addresses why SARS‐CoV‐2 is so different from other viruses and how regenerative medicine is poised… read more here.
Keywords: medicine; opportunities fighting; therapeutic opportunities; covid ... See more keywords
The interplay between lipid and Aβ amyloid homeostasis in Alzheimer's Disease: risk factors and therapeutic opportunities.
Sign Up to like & getrecommendations! Published in 2021 at "Chemistry and physics of lipids"
DOI: 10.1016/j.chemphyslip.2021.105072
Abstract: Alzheimer's Diseases (AD) is characterized by the accumulation of amyloid deposits of Aβ peptide in the brain. Besides genetic background, the presence of other diseases and an unhealthy lifestyle are known risk factors for AD… read more here.
Keywords: lipid amyloid; interplay lipid; risk factors; therapeutic opportunities ... See more keywords
Exploring the pathophysiology of post-sepsis syndrome to identify therapeutic opportunities
Sign Up to like & getrecommendations! Published in 2020 at "EBioMedicine"
DOI: 10.1016/j.ebiom.2020.103044
Abstract: Sepsis is a major health problem worldwide. As the number of sepsis cases increases, so does the number of sepsis survivors who suffer from “post-sepsis syndrome” after hospital discharge. This syndrome involves deficits in multiple… read more here.
Keywords: sepsis; therapeutic opportunities; pathophysiology; post sepsis ... See more keywords
Current and novel therapeutic opportunities for systemic therapy in biliary cancer
Sign Up to like & getrecommendations! Published in 2020 at "British Journal of Cancer"
DOI: 10.1038/s41416-020-0987-3
Abstract: Biliary tract cancers (BTCs) are a group of rare and aggressive malignancies that arise in the biliary tree within and outside the liver. Beyond surgical resection, which is beneficial for only a small proportion of… read more here.
Keywords: cancer current; current novel; opportunities systemic; therapeutic opportunities ... See more keywords
Chromatin regulatory mechanisms and therapeutic opportunities in cancer
Sign Up to like & getrecommendations! Published in 2019 at "Nature Cell Biology"
DOI: 10.1038/s41556-018-0258-1
Abstract: Research over the past several decades has unmasked a major contribution of disrupted chromatin regulatory processes to human disease, particularly cancer. Advances in genome-wide technologies have highlighted frequent mutations in genes encoding chromatin-associated proteins, identified… read more here.
Keywords: mechanisms therapeutic; regulatory mechanisms; therapeutic opportunities; chromatin regulatory ... See more keywords
Developmental origins and emerging therapeutic opportunities for childhood cancer
Sign Up to like & getrecommendations! Published in 2019 at "Nature Medicine"
DOI: 10.1038/s41591-019-0383-9
Abstract: Cancer is the leading disease-related cause of death in children in developed countries. Arising in the context of actively growing tissues, childhood cancers are fundamentally diseases of dysregulated development. Childhood cancers exhibit a lower overall… read more here.
Keywords: childhood; developmental origins; childhood cancers; therapeutic opportunities ... See more keywords
Aberrant RNA Splicing and Therapeutic Opportunities in Cancers.
Sign Up to like & getrecommendations! Published in 2021 at "Cancer science"
DOI: 10.1111/cas.15213
Abstract: There has been accumulating evidence that RNA splicing is frequently dysregulated in a variety of cancers and that hotspot mutations affecting key splicing factors, SF3B1, SRSF2 and U2AF1, are commonly enriched across cancers, strongly suggesting… read more here.
Keywords: opportunities cancers; aberrant rna; therapeutic opportunities; rna splicing ... See more keywords
δ-secretase in neurodegenerative diseases: mechanisms, regulators and therapeutic opportunities
Sign Up to like & getrecommendations! Published in 2020 at "Translational Neurodegeneration"
DOI: 10.1186/s40035-019-0179-3
Abstract: Mammalian asparagine endopeptidase (AEP) is a cysteine protease that cleaves its protein substrates on the C-terminal side of asparagine residues. Converging lines of evidence indicate that AEP may be involved in the pathogenesis of several… read more here.
Keywords: diseases mechanisms; secretase neurodegenerative; regulators therapeutic; neurodegenerative diseases ... See more keywords
Astrocyte Reactivity in Alzheimer's Disease: Therapeutic Opportunities to Promote Repair.
Sign Up to like & getrecommendations! Published in 2021 at "Current Alzheimer research"
DOI: 10.2174/1567205018666211029164106
Abstract: Astrocytes are fast climbing the ladder of importance in neurodegenerative disorders, particularly in Alzheimer's disease (AD), with the prominent presence of reactive astrocytes sur- rounding amyloid β- plaques, together with activated microglia. Reactive astrogliosis, implying… read more here.
Keywords: alzheimer disease; disease; therapeutic opportunities; disease therapeutic ... See more keywords
Chondrocyte Aging: The Molecular Determinants and Therapeutic Opportunities
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2021.625497
Abstract: Osteoarthritis (OA) is a joint degenerative disease that is an exceedingly common problem associated with aging. Aging is the principal risk factor for OA, but damage-related physiopathology of articular chondrocytes probably drives the mechanisms of… read more here.
Keywords: aging molecular; molecular determinants; determinants therapeutic; therapeutic opportunities ... See more keywords