NMR Assessment of Therapeutic Peptides and Proteins: Correlations That Reveal Interactions and Motions
Sign Up to like & getrecommendations! Published in 2019 at "ChemBioChem"
DOI: 10.1002/cbic.201900296
Abstract: NMR measurements of rotational and translational diffusion are used to characterize the solution behavior of a wide variety of therapeutic proteins and peptides. The timescales of motions sampled in these experiments reveal complicated intrinsic solution… read more here.
Keywords: peptides proteins; assessment therapeutic; therapeutic peptides; proteins correlations ... See more keywords
Interaction of Therapeutic d-Peptides with Aβ42 Monomers, Thermodynamics, and Binding Analysis.
Sign Up to like & getrecommendations! Published in 2022 at "ACS chemical neuroscience"
DOI: 10.1021/acschemneuro.2c00102
Abstract: The aggregation of the amyloid-β (Aβ) peptide is a major hallmark of Alzheimer's disease. This peptide can aggregate into oligomers, proto-fibrils, and mature fibrils, which eventually assemble into amyloid plaques. The peptide monomers are the… read more here.
Keywords: peptides monomers; interaction therapeutic; therapeutic peptides; thermodynamics binding ... See more keywords
Characterization of Ultraviolet Photoreactions in Therapeutic Peptides by Femtosecond Laser Catalysis and Mass Spectrometry
Sign Up to like & getrecommendations! Published in 2019 at "ACS Omega"
DOI: 10.1021/acsomega.9b01749
Abstract: Peptides and proteins have diverse ultraviolet (UV) photoreaction pathways that can be activated by the energy of the UV photons absorbed. Simple light sources such as lamps are conventionally used to study these photoreactions in… read more here.
Keywords: femtosecond laser; therapeutic peptides; characterization ultraviolet; photoreactions therapeutic ... See more keywords
The Rational Design of Therapeutic Peptides for Aminopeptidase N using a Substrate-Based Approach
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/s41598-017-01542-5
Abstract: The M1 family of metalloproteases represents a large number of exopeptidases that cleave single amino acid residues from the N-terminus of peptide substrates. One member of this family that has been well studied is aminopeptidase… read more here.
Keywords: rational design; therapeutic peptides; design therapeutic; peptides aminopeptidase ... See more keywords
Stereochemical inversion as a route to improved biophysical properties of therapeutic peptides exemplified by glucagon
Sign Up to like & getrecommendations! Published in 2019 at "Communications Chemistry"
DOI: 10.1038/s42004-018-0100-5
Abstract: Peptides and small proteins are attractive therapeutic candidates due to their inherent selectivity and limited off-target effects. Unfortunately, their potential is often hindered by unfavorable physicochemical properties. This is particularly true in the case of… read more here.
Keywords: glucagon; aqueous solubility; therapeutic peptides; stereochemical inversion ... See more keywords
PreTP-EL: prediction of therapeutic peptides based on ensemble learning.
Sign Up to like & getrecommendations! Published in 2021 at "Briefings in bioinformatics"
DOI: 10.1093/bib/bbab358
Abstract: Therapeutic peptides are important for understanding the correlation between peptides and their therapeutic diagnostic potential. The therapeutic peptides can be further divided into different types based on therapeutic function sharing different characteristics. Although some computational… read more here.
Keywords: therapeutic peptides; peptides based; prediction therapeutic; ensemble learning ... See more keywords
Structured Sparse Regularized TSK Fuzzy System for predicting therapeutic peptides
Sign Up to like & getrecommendations! Published in 2022 at "Briefings in bioinformatics"
DOI: 10.1093/bib/bbac135
Abstract: Therapeutic peptides act on the skeletal system, digestive system and blood system, have antibacterial properties and help relieve inflammation. In order to reduce the resource consumption of wet experiments for the identification of therapeutic peptides,… read more here.
Keywords: therapeutic peptides; system; structured sparse; sparse regularized ... See more keywords
TPpred-ATMV: therapeutic peptide prediction by adaptive multi-view tensor learning model.
Sign Up to like & getrecommendations! Published in 2022 at "Bioinformatics"
DOI: 10.1093/bioinformatics/btac200
Abstract: MOTIVATION Therapeutic peptide prediction is important for the discovery of efficient therapeutic peptides and drug development. Researchers have developed several computational methods to identify different therapeutic peptide types. However, these computational methods focus on identifying… read more here.
Keywords: therapeutic peptides; therapeutic peptide; multi view; tensor learning ... See more keywords
PreTP-2L: identification of therapeutic peptides and their types using two-layer ensemble learning framework
Sign Up to like & getrecommendations! Published in 2023 at "Bioinformatics"
DOI: 10.1093/bioinformatics/btad125
Abstract: Abstract Motivation Therapeutic peptides play an important role in immune regulation. Recently various therapeutic peptides have been used in the field of medical research, and have great potential in the design of therapeutic schedules. Therefore,… read more here.
Keywords: therapeutic peptides; therapeutic peptide; ensemble learning; peptides types ... See more keywords
Deep learning-based multi-functional therapeutic peptides prediction with a multi-label focal dice loss function
Sign Up to like & getrecommendations! Published in 2023 at "Bioinformatics"
DOI: 10.1093/bioinformatics/btad334
Abstract: Abstract Motivation With the great number of peptide sequences produced in the postgenomic era, it is highly desirable to identify the various functions of therapeutic peptides quickly. Furthermore, it is a great challenge to predict… read more here.
Keywords: therapeutic peptides; focal dice; dice loss; multi label ... See more keywords
EnDL-HemoLyt: Ensemble Deep Learning-based Tool for Identifying Therapeutic Peptides with Low Hemolytic Activity.
Sign Up to like & getrecommendations! Published in 2023 at "IEEE journal of biomedical and health informatics"
DOI: 10.1109/jbhi.2023.3264941
Abstract: Low hemolytic therapeutic peptides have gained an edge over small molecule-based medicines. However, finding low hemolytic peptides in laboratory is time-consuming, costly and necessitates the use of mammalian red blood cells. Therefore, wet-lab researchers often… read more here.
Keywords: therapeutic peptides; low hemolytic; proposed framework; learning ... See more keywords