Harnessing the Therapeutic Potential of Biomacromolecules through Intracellular Delivery of Nucleic Acids, Peptides, and Proteins
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DOI: 10.1002/adhm.202102600
Abstract: Biomacromolecules have long been at the leading edge of academic and pharmaceutical drug development and clinical translation. With the clinical advances of new therapeutics, such as monoclonal antibodies and nucleic acids, the array of medical… read more here.
Keywords: nucleic acids; therapeutic potential; harnessing therapeutic; intracellular delivery ... See more keywords
Injectable Glucose‐Releasing Microgels Enhance the Survival and Therapeutic Potential of Transplanted MSCs Under Ischemic Conditions
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DOI: 10.1002/adhm.202401724
Abstract: Mesenchymal stem cell (MSC)‐based therapies show potential to treat ischemic diseases owing to their versatile functions. However, sustaining MSC viability and therapeutic efficacy in ischemic tissues postengraftment remains a significant challenge. This is because, although… read more here.
Keywords: glucose releasing; ischemic conditions; injectable glucose; therapeutic potential ... See more keywords
The anti‐Acinetobacter baumannii therapeutic potential of azole hybrids: A mini‐review
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DOI: 10.1002/ardp.202400592
Abstract: Acinetobacter baumannii is one of the major causes of severe hospital‐ and community‐acquired infections, posing a significant threat to human lives. A. baumannii has already generated resistance to almost all of the currently available antibiotics,… read more here.
Keywords: azole hybrids; acinetobacter baumannii; baumannii; potential azole ... See more keywords
The Therapeutic Potential of Berberine in Lung Cancer
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DOI: 10.1002/ardp.70013
Abstract: Lung cancer has the second‐highest incidence rate after breast cancer and remains the leading cause of cancer‐related mortality. The 1‐year survival rate for lung cancer patients is below 50%, highlighting the urgent need for novel… read more here.
Keywords: cancer; lung cancer; therapeutic potential; bbr ... See more keywords
Therapeutic Potential of Agmatine in Essential Tremor Through Regulation of Lingo‐1 and Inflammatory Pathways
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DOI: 10.1002/brb3.70241
Abstract: Essential tremor (ET) is a prevalent movement disorder, yet current therapeutic options remain limited. Emerging evidence implicates leucine‐rich repeat and immunoglobulin‐like domain‐containing protein (Lingo‐1) and neuroinflammation in the pathophysiology of ET. This study aimed to… read more here.
Keywords: tremor; therapeutic potential; agmatine essential; essential tremor ... See more keywords
Therapeutic Potential of Trolox and Its Synthetic Derivatives as Multifunctional Bioactive Molecules in Periodontal Disease Management.
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DOI: 10.1002/ddr.70200
Abstract: Periodontal disease is a chronic inflammatory problem that has destructive effects on the tooth‐supporting tissues. This disease affects a large portion of the population, influencing overall health and quality of life, and significant socioeconomic burden.… read more here.
Keywords: disease; therapeutic potential; trolox synthetic; periodontal disease ... See more keywords
Therapeutic Potential of G Protein‐Coupled Receptors Against Nonalcoholic Steatohepatitis
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DOI: 10.1002/hep.31852
Abstract: Nonalcoholic steatohepatitis (NASH), the advanced stage of nonalcoholic fatty liver disease (NAFLD), affects approximately 6% of the population worldwide and is strongly associated with cardiometabolic disorders, placing subjects at a sharply increased risk of end-stage… read more here.
Keywords: protein coupled; therapeutic potential; coupled receptors; nonalcoholic steatohepatitis ... See more keywords
Therapeutic potential of carfilzomib, an irreversible proteasome inhibitor, against acetaminophen‐induced hepatotoxicity in mice
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Biochemical and Molecular Toxicology"
DOI: 10.1002/jbt.21877
Abstract: Overdose of acetaminophen (APAP) is often associated with hepatotoxicity. Carfilzomib (CFZ) shows multiple pharmacological activities including anti‐inflammatory potential. Therefore, this study was undertaken to evaluate the possible therapeutic effects of CFZ against APAP‐induced hepatotoxicity. Hepatotoxicity… read more here.
Keywords: induced hepatotoxicity; cfz post; hepatotoxicity; therapeutic potential ... See more keywords
Therapeutic Potential of Exosomal miRNAs: New Insights and Future Directions
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DOI: 10.1002/jbt.70270
Abstract: Modern advancements in medicine include developing targeted drug delivery systems in the medical field, which are designed to unravel the potential of therapeutic products and overcome the barriers to the effectiveness of current approaches. Various… read more here.
Keywords: potential exosomal; new insights; mirnas new; therapeutic potential ... See more keywords
Therapeutic Potential of Curcumin in Treatment of Pancreatic Cancer: Current Status and Future Perspectives
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DOI: 10.1002/jcb.25897
Abstract: Pancreatic cancer is among the leading cause of deaths due to cancer with extremely poor prognosis. Gemcitabine is being used in the treatment of patient with pancreatic ductal adenocarcinoma (PDAC), although, the response rate is… read more here.
Keywords: potential curcumin; treatment; pancreatic cancer; cancer ... See more keywords
Downregulation of microRNA‐214 improves therapeutic potential of allogeneic bone marrow–derived mesenchymal stem cell by targeting PIM‐1 in rats with acute liver failure
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cellular Biochemistry"
DOI: 10.1002/jcb.28560
Abstract: Acute liver failure (ALF) is a disease resulted from diverse etiology, which generally leads to a rapid degenerated hepatic function. However, transplantation bone marrow–derived mesenchymal stem cells (BMSCs) transplantation has been suggested to relieve ALF.… read more here.
Keywords: liver failure; acute liver; transplantation; expression ... See more keywords