Polyampholyte-Based Polymer Hydrogels for the Long-Term Storage, Protection and Delivery of Therapeutic Proteins.
Sign Up to like & getrecommendations! Published in 2023 at "Advanced healthcare materials"
DOI: 10.1002/adhm.202203253
Abstract: Protein storage and delivery are crucial for biomedical applications such as protein therapeutics and recombinant proteins. Lack of proper protocols result in denaturation of proteins, rendering them inactive and manifesting undesired side-effects. In this study,… read more here.
Keywords: polyampholyte based; long term; therapeutic proteins; polymer ... See more keywords
Directed Evolution Enables Simultaneous Controlled Release of Multiple Therapeutic Proteins from Biopolymer‐Based Hydrogels
Sign Up to like & getrecommendations! Published in 2022 at "Advanced Materials"
DOI: 10.1002/adma.202202612
Abstract: With the advent of increasingly complex combination strategies of biologics, independent control over their delivery is the key to their efficacy; however, current approaches are hindered by the limited independent tunability of their release rates.… read more here.
Keywords: multiple therapeutic; therapeutic proteins; controlled release; release ... See more keywords
Key Physicochemical Characteristics Influencing ADME Properties of Therapeutic Proteins.
Sign Up to like & getrecommendations! Published in 2019 at "Advances in experimental medicine and biology"
DOI: 10.1007/978-981-13-7709-9_6
Abstract: Therapeutic proteins are a rapidly growing class of drugs in clinical settings. The pharmacokinetics (PK) of therapeutic proteins relies on their absorption, distribution, metabolism, and excretion (ADME) properties. Moreover, the ADME properties of therapeutic proteins… read more here.
Keywords: therapeutic proteins; key physicochemical; adme properties; properties therapeutic ... See more keywords
Engineering of lactic acid bacteria for delivery of therapeutic proteins and peptides
Sign Up to like & getrecommendations! Published in 2019 at "Applied Microbiology and Biotechnology"
DOI: 10.1007/s00253-019-09628-y
Abstract: Lactic acid bacteria (LAB) have a long-term history of use in food industry and are becoming attractive for use in therapy on account of their safety, intrinsic beneficial health effects, and considerable biotechnological potential. The… read more here.
Keywords: engineering; delivery therapeutic; therapeutic proteins; delivery ... See more keywords
Engineered protein nanodrug as an emerging therapeutic tool
Sign Up to like & getrecommendations! Published in 2022 at "Nano Research"
DOI: 10.1007/s12274-022-4103-2
Abstract: Functional proteins are the most versatile macromolecules. They can be obtained by extraction from natural sources or by genetic engineering technologies. The outstanding selectivity, specificity, binding activity, and biocompatibility endow engineered proteins with outstanding performance… read more here.
Keywords: emerging therapeutic; therapeutic tool; therapeutic proteins; engineered protein ... See more keywords
Ionic liquids as biocompatible stabilizers of proteins
Sign Up to like & getrecommendations! Published in 2018 at "Biophysical Reviews"
DOI: 10.1007/s12551-018-0407-6
Abstract: Ionic liquids (ILs) have recently emerged as versatile solvents and additives in the field of biotechnology, particularly as stabilizers of proteins and enzymes. Of interest to the biotechnology industry is the formulation of stable biopharmaceuticals,… read more here.
Keywords: therapeutic proteins; liquids biocompatible; stabilizers proteins; ionic liquids ... See more keywords
Emerging biomaterials for downstream manufacturing of therapeutic proteins.
Sign Up to like & getrecommendations! Published in 2019 at "Acta biomaterialia"
DOI: 10.1016/j.actbio.2019.03.015
Abstract: Downstream processing is considered one of the most challenging phases of industrial manufacturing of therapeutic proteins, accounting for a large portion of the total production costs. The growing demand for therapeutic proteins in the biopharmaceutical… read more here.
Keywords: biomaterials downstream; therapeutic proteins; downstream processing; manufacturing therapeutic ... See more keywords
Integration and digitalization in the manufacturing of therapeutic proteins
Sign Up to like & getrecommendations! Published in 2022 at "Chemical Engineering Science"
DOI: 10.1016/j.ces.2021.117159
Abstract: Abstract The biopharmaceutical market has experienced a tremendous growth in the last years. However, this growth should be balanced considering the difficulty in bioproduct development and the associated high manufacturing costs. These limitations are pushing… read more here.
Keywords: therapeutic proteins; digitalization; digitalization manufacturing; manufacturing therapeutic ... See more keywords
Protein nanocage architectures for the delivery of therapeutic proteins
Sign Up to like & getrecommendations! Published in 2021 at "Current Opinion in Colloid and Interface Science"
DOI: 10.1016/j.cocis.2020.101395
Abstract: Abstract Protein assemblies with cage-like structures are found widely in Nature with a large diversity of structural properties and functionalities. These architectures provide both inspiration for biomimetic design and templates for bioengineering. Inspired by the… read more here.
Keywords: therapeutic proteins; protein nanocage; nanocage architectures; delivery ... See more keywords
Do not flick or drop off-label use plastic syringes in handling therapeutic proteins before administration.
Sign Up to like & getrecommendations! Published in 2020 at "International Journal of Pharmaceutics"
DOI: 10.1016/j.ijpharm.2020.119704
Abstract: Abstract This study investigates the formation of subvisible particles formed by external stresses produced such as flicking and dropping syringes. Flow imaging was used to visualize and quantify microparticles from 1 μm to over 25 μm as… read more here.
Keywords: therapeutic proteins; silicone oil; oil; flick drop ... See more keywords
Synthesis and in vitro characterization of a pH-responsive chitosan- polyethylenimine nanosystem for the delivery of therapeutic proteins
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Drug Delivery Science and Technology"
DOI: 10.1016/j.jddst.2017.03.022
Abstract: Abstract The purpose of this study was to design and characterize Bovine Serum Albumin (BSA)-loaded chitosan (CHT)-based nanoparticles for the potential delivery of therapeutic proteins. Tripolyphosphate (TPP) was used as a polyanionic agent to synthesize… read more here.
Keywords: therapeutic proteins; bsa loaded; delivery; size ... See more keywords