The tumor microenvironment as driver of stemness and therapeutic resistance in breast cancer: New challenges and therapeutic opportunities.
Sign Up to like & getrecommendations! Published in 2021 at "Cellular oncology"
DOI: 10.1007/s13402-021-00634-9
Abstract: BACKGROUND Breast cancer (BC), the second most common cause of cancer-related deaths, remains a significant threat to the health and wellness of women worldwide. The tumor microenvironment (TME), comprising cellular components, such as cancer-associated fibroblasts… read more here.
Keywords: therapeutic resistance; breast cancer; tme; cancer ... See more keywords
Physical confinement during cancer cell migration triggers therapeutic resistance and cancer stem cell-like behavior.
Sign Up to like & getrecommendations! Published in 2021 at "Cancer letters"
DOI: 10.1016/j.canlet.2021.01.020
Abstract: Metastasized cancer cells have an increased resistance to therapies leading to a drastic decrease in patient survival rates. However, our understanding of the cause for this enhanced resistance is lacking. In this study, we report… read more here.
Keywords: cancer stem; therapeutic resistance; stem cell; resistance ... See more keywords
Interplay between tumor microenvironment and partial EMT as the driver of tumor progression
Sign Up to like & getrecommendations! Published in 2021 at "iScience"
DOI: 10.1016/j.isci.2021.102113
Abstract: Summary Epithelial-to-mesenchymal transition (EMT), an evolutionary conserved phenomenon, has been extensively studied to address the unresolved variable treatment response across therapeutic regimes in cancer subtypes. EMT has long been envisaged to regulate tumor invasion, migration,… read more here.
Keywords: tumor progression; emt; therapeutic resistance; pemt ... See more keywords
The pan-therapeutic resistance of disseminated tumor cells: role of phenotypic plasticity and the metastatic microenvironment.
Sign Up to like & getrecommendations! Published in 2019 at "Seminars in cancer biology"
DOI: 10.1016/j.semcancer.2019.07.021
Abstract: Cancer metastasis is the leading cause of mortality in patients with solid tumors. The majority of these deaths are associated with metastatic disease that occurs after a period of clinical remission, anywhere from months to… read more here.
Keywords: therapeutic resistance; disseminated tumor; pan therapeutic; tumor cells ... See more keywords
Tumor-associated neutrophils: orchestrating cancer pathobiology and therapeutic resistance
Sign Up to like & getrecommendations! Published in 2021 at "Expert Opinion on Therapeutic Targets"
DOI: 10.1080/14728222.2021.1954162
Abstract: ABSTRACT Introduction: Neutrophils or polymorphonuclear cells (PMNs) account for a considerable portion of the tumor immune stroma. Emerging single-cell transcriptomic analyses have elucidated the striking cellular heterogeneity of PMNs during homeostasis and pathologic conditions and… read more here.
Keywords: pathobiology therapeutic; therapeutic resistance; cancer pathobiology; resistance ... See more keywords
Targeting KRAS G12C mutations in colorectal cancer
Sign Up to like & getrecommendations! Published in 2022 at "Gastroenterology Report"
DOI: 10.1093/gastro/goac083
Abstract: Abstract With the advent of Kirsten rat sarcoma viral oncogene homologue G12C (KRAS G12C) inhibitors, RAS is no longer considered undruggable. For the suppression of RAS, new therapeutic approaches have been suggested. However, current clinical… read more here.
Keywords: targeting kras; kras g12c; colorectal cancer; therapeutic resistance ... See more keywords
P06.12.B Microbiota-gut-brain axis in glioblastoma development and therapeutic resistance
Sign Up to like & getrecommendations! Published in 2024 at "Neuro-Oncology"
DOI: 10.1093/neuonc/noae144.149
Abstract: Glioblastoma (GB) is the most common subtype of glioma in adults. Despite treatment through tumor resection associated with chemo and radiotherapies, this cancer still has a very poor prognosis. Factors contributing to etiology, pathogenesis, or… read more here.
Keywords: development therapeutic; therapeutic resistance; gut; microbiota ... See more keywords
P01.26.B M6A-MEDIATED UPREGULATION OF SOX11 DRIVES CHROMATIN REMODELING AND STEMNESS, CONTRIBUTING TO THERAPEUTIC RESISTANCE IN H3 K27M-MUTANT SPINAL CORD GLIOMAS
Sign Up to like & getrecommendations! Published in 2025 at "Neuro-Oncology"
DOI: 10.1093/neuonc/noaf193.106
Abstract: Spinal cord gliomas are rare intramedullary tumors (0.25-0.4/100,000 annually) with distinct molecular features compared to intracranial gliomas. H3 K27M-mutant spinal gliomas show strong stem-like traits and intrinsic resistance to therapy. Our preliminary data identified m6A… read more here.
Keywords: mutant spinal; resistance; sox11; therapeutic resistance ... See more keywords
CD44: a key regulator of iron metabolism, redox balance, and therapeutic resistance in cancer stem cells
Sign Up to like & getrecommendations! Published in 2025 at "Stem Cells"
DOI: 10.1093/stmcls/sxaf024
Abstract: Abstract CD44, a multifunctional cell surface protein, has emerged as a pivotal regulator in cancer stem cell (CSC) biology, orchestrating processes such as stemness, metabolic reprogramming, and therapeutic resistance. Recent studies have identified a critical… read more here.
Keywords: iron metabolism; resistance; metabolism redox; stem ... See more keywords
Ribosome Biogenesis: A Central Player in Cancer Metastasis and Therapeutic Resistance
Sign Up to like & getrecommendations! Published in 2022 at "Cancer Research"
DOI: 10.1158/0008-5472.can-21-4087
Abstract: Abstract Ribosomes are a complex ensemble of rRNA and ribosomal proteins that function as mRNA translation machines. Ribosome biogenesis is a multistep process that begins in the nucleolus and concludes in the cytoplasm. The process… read more here.
Keywords: biogenesis; ribosome biogenesis; cancer; therapeutic resistance ... See more keywords
Abstract 1745: Targeting therapeutic resistance of esophageal adenocarcinoma through modulating the epithelial-to-mesenchymal transition via NFκB-mediated signaling
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-1745
Abstract: Esophageal adenocarcinoma (EAC) is the major subtype of esophageal cancer in Westernized countries, characterized by rising incidence and poor prognosis with a five-year survival rate less than 20%. Only 15% of EAC patients have a… read more here.
Keywords: therapeutic resistance; epithelial mesenchymal; treatment; cancer ... See more keywords