The good and bad of therapeutic strategies that directly target α‐synuclein
Sign Up to like & getrecommendations! Published in 2019 at "IUBMB Life"
DOI: 10.1002/iub.2194
Abstract: Synucleinopathies are neurodegenerative diseases characterized by the accumulation of either neuronal/axonal or glial insoluble proteinaceous aggregates mainly composed of α‐synuclein (α‐syn). Among them, the most common disorders are Parkinson's disease, dementia with Lewy bodies, multiple… read more here.
Keywords: state; syn; good bad; pathology ... See more keywords
Selectively targeting cancer stem cells: Current and novel therapeutic strategies and approaches in the effective eradication of cancer
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DOI: 10.1002/iub.2524
Abstract: Cancer stem cells (CSCs) are a subgroup of cells in malignant cancers, which possess self‐renewal capacity, tumor‐initiating capability, and pluripotency, as well as being responsible for tumor maintenance, metastasis, relapse, and chemoresistance. The treatment modalities… read more here.
Keywords: cancer stem; therapeutic strategies; cancer; stem cells ... See more keywords
Critical limb ischemia: Current and novel therapeutic strategies
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DOI: 10.1002/jcp.28141
Abstract: Critical limb ischemia (CLI) is the advanced stage of peripheral artery disease spectrum and is defined by limb pain or impending limb loss because of compromised blood flow to the affected extremity. Current conventional therapies… read more here.
Keywords: cli treatment; limb ischemia; critical limb; therapeutic strategies ... See more keywords
Implications of exosomes as diagnostic and therapeutic strategies in cancer
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DOI: 10.1002/jcp.28875
Abstract: Exosomes offer a new perspective on the biology of cancer with both diagnostic and therapeutic concepts. Due to the cell‐to‐cell association, exosomes are involved in the progression, metastasis, and therapeutic efficacy of the tumor. They… read more here.
Keywords: diagnostic therapeutic; therapeutic strategies; implications exosomes; cancer ... See more keywords
Therapeutic strategies: Surgery for human papillomavirus‐associated oropharyngeal carcinoma
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Surgical Oncology"
DOI: 10.1002/jso.26695
Abstract: Treatment of oropharyngeal cancer (OPC) has undergone considerable evolution since the discovery of human papillomavirus (HPV)‐associated OPC. It is widely understood that HPV OPC affects a younger population and standard treatment offers improved oncologic outcomes… read more here.
Keywords: treatment; therapeutic strategies; strategies surgery; hpv opc ... See more keywords
Therapeutic Strategies in EGFR Mutant Non-Small Cell Lung Cancer
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DOI: 10.1007/s11864-018-0570-9
Abstract: Opinion statementNon-small cell lung cancer (NSCLC) harboring epidermal growth receptor (EGFR) mutation has distinct genomic characteristics. Introduction of systemic treatments that specifically targeted actionable EGFR mutations has changed the therapeutic paradigm in this group of… read more here.
Keywords: therapeutic strategies; cell lung; lung cancer; cancer ... See more keywords
New Therapeutic Strategies for Lewy Body Dementias
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DOI: 10.1007/s11910-017-0778-2
Abstract: This article reviews current treatment strategies and recent advances for the Lewy body dementias (LBDs). Current available symptom treatment strategies are based on monoaminergic, cholinergic and glutaminergic neurotransmitter systems. Relatively robust evidence exists for cholinesterase… read more here.
Keywords: disease; therapeutic strategies; new therapeutic; lewy body ... See more keywords
Therapeutic Strategies to Treat or Prevent Off Episodes in Adults with Parkinson’s Disease
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DOI: 10.1007/s40265-020-01310-2
Abstract: Parkinson’s disease is a chronic, neurodegenerative disease, which manifests with a mixture of motor, cognitive and behavioural symptoms. Levodopa is the most effective antiparkinsonian treatment to date, although chronic use engenders a mixture of complications… read more here.
Keywords: episodes adults; treat prevent; therapeutic strategies; prevent episodes ... See more keywords
Insult-induced aberrant hippocampal neurogenesis: Functional consequences and possible therapeutic strategies
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DOI: 10.1016/j.bbr.2019.112032
Abstract: Adult hippocampal neurogenesis plays a critical role in a wide spectrum of hippocampus-dependent functions. Brain pathologies that involve the hippocampus like epilepsy, stroke, and traumatic brain injury, are commonly associated with cognitive impairments and mood… read more here.
Keywords: hippocampus; neurogenesis; hippocampal neurogenesis; insult induced ... See more keywords
Leveraging coronavirus binding to gangliosides for innovative vaccine and therapeutic strategies against COVID-19
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DOI: 10.1016/j.bbrc.2020.10.015
Abstract: Covid-19 is an infectious respiratory disease due to a coronavirus named SARS-CoV-2. A critical step of the infection cycle is the binding of the virus spike S protein to the cellular ACE-2 receptor. This interaction… read more here.
Keywords: innovative vaccine; vaccine therapeutic; therapeutic strategies; coronavirus ... See more keywords
Osimertinib resistance in non-small cell lung cancer: Mechanisms and therapeutic strategies.
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DOI: 10.1016/j.canlet.2018.02.004
Abstract: Given the successful identification of epidermal growth factor receptor EGFR T790M, the third-generation EGFR tyrosine kinase inhibitor (TKI), osimertinib (OSI, AZD9291), was developed to target EGFR T790M mutation. OSI was approved for the treatment of… read more here.
Keywords: therapeutic strategies; cell lung; resistance; non small ... See more keywords