Optogenetic manipulation of astrocytes from synapses to neuronal networks: A potential therapeutic strategy for neurodegenerative diseases
Sign Up to like & getrecommendations! Published in 2019 at "Glia"
DOI: 10.1002/glia.23693
Abstract: Astrocytes are the most widespread and heterogeneous glial cells in the central nervous system and key regulators for brain development. They are capable of receiving neurotransmitters produced by synaptic activities and regulating synaptic functions by… read more here.
Keywords: therapeutic strategy; neurodegenerative diseases; potential therapeutic; optogenetic manipulation ... See more keywords
Moving towards a novel therapeutic strategy for hyperammonemia that targets glutamine metabolism
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Inherited Metabolic Disease"
DOI: 10.1002/jimd.12540
Abstract: Patients with urea cycle disorders intermittently develop episodes of decompensation with hyperammonemia. Although such an episode is often associated with starvation and catabolism, its molecular basis is not fully understood. First, we attempted to elucidate… read more here.
Keywords: moving towards; novel therapeutic; therapeutic strategy; starvation ... See more keywords
Targeting Aged Astrocytes May Be a New Therapeutic Strategy in Parkinson's Disease
Sign Up to like & getrecommendations! Published in 2018 at "Movement Disorders"
DOI: 10.1002/mds.27387
Abstract: CHWG holds a MRC Clinician Scientist fellowship, and receives grants from the Rosetrees Trust, the Evelyn Trust and Addenbrooke’s Charitable Trust. She is also supported by the NIHR Cambridge Biomedical Research Centre. KMS holds a… read more here.
Keywords: astrocytes may; therapeutic strategy; targeting aged; may new ... See more keywords
A Triple Therapeutic Strategy with Antiexosomal Iron Efflux for Enhanced Ferroptosis Therapy and Immunotherapy.
Sign Up to like & getrecommendations! Published in 2022 at "Small"
DOI: 10.1002/smll.202201704
Abstract: Ferroptosis is a form of regulated cell death which can not only kill tumor cells but also enhance immunogenicity of tumor cells, and it is evidenced to be involved in a variety of tumor treatments,… read more here.
Keywords: triple therapeutic; iron; therapy; therapeutic strategy ... See more keywords
Activating Autophagy as a Therapeutic Strategy for Parkinson’s Disease
Sign Up to like & getrecommendations! Published in 2018 at "CNS Drugs"
DOI: 10.1007/s40263-018-0497-5
Abstract: Parkinson’s disease is a progressive neurodegenerative disease characterized by Lewy body pathology of which the primary constituent is aggregated misfolded alpha-synuclein protein. Currently, there are no clinical therapies for treatment of the underlying alpha-synuclein dysfunction… read more here.
Keywords: therapeutic strategy; disease; parkinson disease; alpha synuclein ... See more keywords
COVID-19: the crucial role of the nose
Sign Up to like & getrecommendations! Published in 2020 at "Brazilian Journal of Otorhinolaryngology"
DOI: 10.1016/j.bjorl.2020.08.001
Abstract: We have followed with a great interest the article by Lavinsky et al. and herein we present a simple additional therapeutic strategy against SARS-COV-2. As recently demonstrated, climatic factors such as latitude, temperature, and humidity… read more here.
Keywords: respiratory infections; therapeutic strategy; covid crucial; temperature humidity ... See more keywords
Targeting lipid metabolism of cancer cells: A promising therapeutic strategy for cancer.
Sign Up to like & getrecommendations! Published in 2017 at "Cancer letters"
DOI: 10.1016/j.canlet.2017.05.002
Abstract: One of the most important metabolic hallmarks of cancer cells is deregulation of lipid metabolism. In addition, enhancing de novo fatty acid (FA) synthesis, increasing lipid uptake and lipolysis have also been considered as means… read more here.
Keywords: therapeutic strategy; metabolism cancer; cancer cells; cancer ... See more keywords
Research article miR-21-5p: A viable therapeutic strategy for regulating intraocular pressure.
Sign Up to like & getrecommendations! Published in 2020 at "Experimental eye research"
DOI: 10.1016/j.exer.2020.108197
Abstract: Lowering intraocular pressure (IOP) is the most effective treatment of glaucoma, however most of the current available glaucoma drugs target a single molecule. MicroRNAs (miRNAs) are noncoding RNAs that target a network of molecules. This… read more here.
Keywords: intraocular pressure; mir; therapeutic strategy; research ... See more keywords
Oxidative stress mediated anti-leishmanial activity of endoperoxides represent a new therapeutic strategy in Leishmaniasis
Sign Up to like & getrecommendations! Published in 2018 at "Free Radical Biology and Medicine"
DOI: 10.1016/j.freeradbiomed.2018.04.537
Abstract: Endoperoxides kill malaria parasites via cleavage of their endoperoxide bridge by heme or iron, leading to generation of cytotoxic oxygen-centered radicals. In view of the impaired anti-oxidant defense and high iron content of Leishmania parasites,… read more here.
Keywords: therapeutic strategy; activity; stress mediated; mediated anti ... See more keywords
CD47-targeting antibodies as a novel therapeutic strategy in hematologic malignancies
Sign Up to like & getrecommendations! Published in 2021 at "Leukemia Research Reports"
DOI: 10.1016/j.lrr.2021.100268
Abstract: CD47 is a surface glycoprotein expressed by host cells to impede phagocytosis upon binding to macrophage SIRPα, thereby represents an immune checkpoint known as the “don't-eat-me” signal. However, accumulating evidence shows that solid and hematologic… read more here.
Keywords: cd47 targeting; strategy hematologic; therapeutic strategy; targeting antibodies ... See more keywords
Combining β-Carotene with 5-FU via Polymeric Nanoparticles as a Novel Therapeutic Strategy to Overcome uL3-Mediated Chemoresistance in p53-Deleted Colorectal Cancer Cells
Sign Up to like & getrecommendations! Published in 2023 at "Molecular Pharmaceutics"
DOI: 10.1021/acs.molpharmaceut.2c00876
Abstract: Colorectal cancer (CRC) is one of the leading causes of cancer-related death worldwide. Despite recent therapeutic advancements, resistance to 5-fluorouracil (5-FU) remains a major obstacle to the successful treatment of this disease. We have previously… read more here.
Keywords: novel therapeutic; carotene; therapeutic strategy; colorectal cancer ... See more keywords