MST4 as a novel therapeutic target for autophagy and radiosensitivity in gastric cancer
Sign Up to like & getrecommendations! Published in 2022 at "IUBMB Life"
DOI: 10.1002/iub.2682
Abstract: Mammalian ste20‐like kinase 4 (MST4) and autophagy have been implicated in ailments such as inflammatory and cancers. read more here.
Keywords: therapeutic target; mst4 novel; novel therapeutic; autophagy radiosensitivity ... See more keywords
Necroptotic TNFα‐Syndecan 4‐TNFα Vicious Cycle as a Therapeutic Target for Preventing Temporomandibular Joint Osteoarthritis
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Bone and Mineral Research"
DOI: 10.1002/jbmr.4542
Abstract: Temporomandibular joint osteoarthritis (TMJOA) is a chronic degenerative disease for which the underlying mechanism still remains unclear. Compared with apoptosis and autophagy, necroptosis causes greater harm to tissue homeostasis by releasing damage‐associated molecular patterns (DAMPs).… read more here.
Keywords: necroptosis; vicious cycle; therapeutic target; tnf ... See more keywords
Leptin: A new therapeutic target for treatment of diabetes mellitus
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Cellular Biochemistry"
DOI: 10.1002/jcb.26580
Abstract: Leptin is an endogenous protein having 167 amino acids and is derived from adipocytes. It has tertiary structure that resembles with that of the pro‐inflammatory cytokines family. The fundamental role of leptin is to maintain… read more here.
Keywords: treatment; leptin; diabetes mellitus; role ... See more keywords
In silico identification of natural product inhibitors for γ‐secretase activating protein, a therapeutic target for Alzheimer's disease
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cellular Biochemistry"
DOI: 10.1002/jcb.28316
Abstract: Alzheimer's disease (AD) is clinically characterized by the aggregation of neurotoxic amyloid‐β (Aβ) peptides in the brain. γ‐Secretase catalyzes the reaction of Aβ formation. Inhibition of γ‐secretase activating protein (GSAP) reduces Aβ production without disrupting… read more here.
Keywords: secretase activating; gsap; alzheimer disease; activating protein ... See more keywords
BRG1 is a prognostic indicator and a potential therapeutic target for prostate cancer
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.28161
Abstract: Brahma‐related gene 1 (BRG1) is one of two mutually exclusive ATPases that function as the catalytic subunit of human SWItch/Sucrose NonFermentable (SWI/SNF) chromatin remodeling enzymes. BRG1 has been identified as a tumor suppressor in some… read more here.
Keywords: cancer; expression; prostate cancer; therapeutic target ... See more keywords
Rab7 may be a novel therapeutic target for neurologic diseases as a key regulator in autophagy
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Neuroscience Research"
DOI: 10.1002/jnr.24034
Abstract: Macroautophagy is an evolutionally conserved membrane trafficking pathway that delivers intracellular materials to lysosomes for degradation and recycling. Rab7, as a member of the Rab GTPase superfamily, has a unique role in the regulation of… read more here.
Keywords: rab7 may; disease; neurologic diseases; therapeutic target ... See more keywords
MYO1B as a prognostic biomarker and a therapeutic target in Arecoline-associated oral carcinoma.
Sign Up to like & getrecommendations! Published in 2023 at "Molecular carcinogenesis"
DOI: 10.1002/mc.23535
Abstract: BACKGROUND Arecoline, the main component of betel nut, induces malignant transformation of oral cells through complicated unclear mechanisms. Thus, we aimed to screen the key genes involved in Arecoline-induced oral cancer and further verify their… read more here.
Keywords: oral cancer; arecoline; therapeutic target; key gene ... See more keywords
Nicotinamide adenine dinucleotide emerges as a therapeutic target in aging and ischemic conditions
Sign Up to like & getrecommendations! Published in 2019 at "Biogerontology"
DOI: 10.1007/s10522-019-09805-6
Abstract: Nicotinamide adenine dinucleotide (NAD+) has been described as central coenzyme of redox reactions and is a key regulator of stress resistance and longevity. Aging is a multifactorial and irreversible process that is characterized by a… read more here.
Keywords: adenine dinucleotide; emerges therapeutic; ischemic conditions; nicotinamide adenine ... See more keywords
STAT3 Inhibition for Gastroenteropancreatic Neuroendocrine Tumors: Potential for a New Therapeutic Target?
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Gastrointestinal Surgery"
DOI: 10.1007/s11605-019-04261-6
Abstract: Background Gastroenteropancreatic neuroendocrine tumors (GEP-NETs) are highly vascular neoplasms treated similarly, irrespective of tumor location. The expression of pro-angiogenic factors (STAT3, VEGF, and HIF-1α) and their association with adverse pathologic factors and disease recurrence following… read more here.
Keywords: high stat3; neuroendocrine tumors; expression; gastroenteropancreatic neuroendocrine ... See more keywords
Regulating Autophagy as a Therapeutic Target for Diabetic Nephropathy
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DOI: 10.1007/s11892-017-0879-y
Abstract: Purpose of ReviewAutophagy promotes cellular health in response to various cellular stresses and to changes in nutrient conditions. In this review, we focus on the role of autophagy in the pathogenesis of diabetic nephropathy and… read more here.
Keywords: autophagy therapeutic; regulating autophagy; target; diabetic nephropathy ... See more keywords
Sirtuin 6, a possible therapeutic target for type 2 diabetes
Sign Up to like & getrecommendations! Published in 2017 at "Archives of Pharmacal Research"
DOI: 10.1007/s12272-017-0989-8
Abstract: Sirtuin 6 (SIRT6), one of the seven members of mammalian sirtuin family, localizes in the nucleus and primarily regulates chromatin signaling and genomic integrity. Recent studies established the critical role of SIRT6 in the pathophysiology… read more here.
Keywords: type diabetes; type; target type; sirtuin possible ... See more keywords