Therapeutic Targeting of Hepatic ACSL4 Ameliorates Non-alcoholic Steatohepatitis in Mice.
Sign Up to like & getrecommendations! Published in 2021 at "Hepatology"
DOI: 10.1002/hep.32148
Abstract: Globally, NAFLD is one of the most common liver disorders, with an estimated prevalence rate of more than 30% in men and 15% in women, and an even higher prevalence in people with type 2… read more here.
Keywords: targeting hepatic; acsl4 ameliorates; acsl4; hepatic acsl4 ... See more keywords
Therapeutic Targeting of the Carotid Body for Treating Sleep Apnea in a Pre-clinical Mouse Model.
Sign Up to like & getrecommendations! Published in 2018 at "Advances in experimental medicine and biology"
DOI: 10.1007/978-3-319-91137-3_14
Abstract: Sleep apnea with periodic cessation of breathing during sleep is a highly prevalent respiratory disorder affecting an estimated 10% of adults. Patients with sleep apnea exhibit several co-morbidities including hypertension, stroke, disrupted sleep, and neurocognitive… read more here.
Keywords: apnea; carotid body; sleep apnea; therapeutic targeting ... See more keywords
Therapeutic Targeting of Interleukin-11 Signalling Reduces Pressure Overload–Induced Cardiac Fibrosis in Mice
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Cardiovascular Translational Research"
DOI: 10.1007/s12265-020-10054-z
Abstract: There are currently no specific treatments for cardiac fibrosis. We tested the efficacy of a neutralising anti-IL11 antibody (X203) to reduce cardiac fibrosis in two preclinical models: transverse aortic constriction (TAC) and chronic angiotensin II… read more here.
Keywords: targeting interleukin; fibrosis; cardiac fibrosis; therapeutic targeting ... See more keywords
Regulatory Mechanisms and Novel Therapeutic Targeting Strategies for Protein Tyrosine Phosphatases.
Sign Up to like & getrecommendations! Published in 2018 at "Chemical reviews"
DOI: 10.1021/acs.chemrev.7b00105
Abstract: An appropriate level of protein phosphorylation on tyrosine is essential for cells to react to extracellular stimuli and maintain cellular homeostasis. Faulty operation of signal pathways mediated by protein tyrosine phosphorylation causes numerous human diseases,… read more here.
Keywords: tyrosine phosphatases; regulatory mechanisms; protein tyrosine; therapeutic targeting ... See more keywords
Therapeutic targeting of CK2 in acute and chronic leukemias
Sign Up to like & getrecommendations! Published in 2018 at "Leukemia"
DOI: 10.1038/leu.2017.301
Abstract: CK2 is a ubiquitously expressed, constitutively active Ser/Thr protein kinase, which is considered the most pleiotropic protein kinase in the human kinome. Such a pleiotropy explains the involvement of CK2 in many cellular events. However,… read more here.
Keywords: chronic leukemias; ck2 acute; therapeutic targeting; ck2 ... See more keywords
Therapeutic targeting of the angiopoietin–TIE pathway
Sign Up to like & getrecommendations! Published in 2017 at "Nature Reviews Drug Discovery"
DOI: 10.1038/nrd.2016.278
Abstract: The endothelial angiopoietin (ANG)–TIE growth factor receptor pathway regulates vascular permeability and pathological vascular remodelling during inflammation, tumour angiogenesis and metastasis. Drugs that target the ANG–TIE pathway are in clinical development for oncological and ophthalmological… read more here.
Keywords: tie pathway; targeting angiopoietin; therapeutic targeting; ang tie ... See more keywords
Genomic subtyping and therapeutic targeting of acute erythroleukemia
Sign Up to like & getrecommendations! Published in 2019 at "Nature Genetics"
DOI: 10.1038/s41588-019-0375-1
Abstract: Acute erythroid leukemia (AEL) is a high-risk leukemia of poorly understood genetic basis, with controversy regarding diagnosis in the spectrum of myelodysplasia and myeloid leukemia. We compared genomic features of 159 childhood and adult AEL… read more here.
Keywords: subtyping therapeutic; therapeutic targeting; acute erythroleukemia; targeting acute ... See more keywords
Therapeutic targeting of TRAIL death receptors
Sign Up to like & getrecommendations! Published in 2023 at "Biochemical Society Transactions"
DOI: 10.1042/bst20220098
Abstract: The discovery of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) along with its potent and selective antitumor effects initiated a decades-long search for therapeutic strategies to target the TRAIL pathway. First-generation approaches were focused on the… read more here.
Keywords: generation approaches; trail; targeting trail; trail pathway ... See more keywords
Therapeutic targeting of eukaryotic initiation factor (eIF) 4E.
Sign Up to like & getrecommendations! Published in 2023 at "Biochemical Society transactions"
DOI: 10.1042/bst20220285
Abstract: Fundamental studies unraveled the role of eukaryotic initiation factor (eIF) 4E in mRNA translation and its control. Under physiological conditions, regulation of translation by eIF4E is essential to cellular homeostasis. Under stress, gene flow information… read more here.
Keywords: factor eif; therapeutic targeting; eukaryotic initiation; initiation factor ... See more keywords
Therapeutic Targeting of the Colorectal Tumor Stroma.
Sign Up to like & getrecommendations! Published in 2019 at "Gastroenterology"
DOI: 10.1053/j.gastro.2019.09.045
Abstract: Colorectal tumors have been classified based on histologic factors, genetic factors, and consensus molecular subtypes, which all affect the tumor microenvironment (TME). Elements of the TME serve as therapeutic targets and might be used as… read more here.
Keywords: colorectal tumor; therapeutic targeting; targeting colorectal; tumor stroma ... See more keywords
Therapeutic targeting of isocitrate dehydrogenase mutant AML
Sign Up to like & getrecommendations! Published in 2017 at "Expert Opinion on Investigational Drugs"
DOI: 10.1080/13543784.2017.1317745
Abstract: The last decade has witnessed rapid advances in our understanding of molecular leukemogenesis providing valuable insights from which to explore new therapeutic avenues. Characterization of the muta... read more here.
Keywords: isocitrate dehydrogenase; therapeutic targeting; mutant aml; targeting isocitrate ... See more keywords