The prevalence and prognosis of next‐generation therapeutic targets in metastatic castration‐resistant prostate cancer
Sign Up to like & getrecommendations! Published in 2022 at "Molecular Oncology"
DOI: 10.1002/1878-0261.13320
Abstract: The success of the PROfound, IPATential150, and TheraP trials promoted the transition from sequential treatment to therapeutic targets (TTs)‐guided precision treatment in metastatic castration‐resistant prostate cancer (mCRPC). The objective of this study was to evaluate… read more here.
Keywords: prevalence; prostate; resistant prostate; castration resistant ... See more keywords
A group of novel VEGF splice variants as alternative therapeutic targets in renal cell carcinoma.
Sign Up to like & getrecommendations! Published in 2023 at "Molecular oncology"
DOI: 10.1002/1878-0261.13401
Abstract: The efficacy of anti-angiogenic treatment by targeting VEGF/VEGF receptors in metastatic clear cell renal cell carcinoma (ccRCC) varies from patient to patient. Discovering the reasons behind this variability could lead to the identification of relevant… read more here.
Keywords: cell; renal cell; vegf; therapeutic targets ... See more keywords
Integrative Epigenetic Analysis Reveals Therapeutic Targets to the DNA Methyltransferase Inhibitor Guadecitabine (SGI‐110) in Hepatocellular Carcinoma
Sign Up to like & getrecommendations! Published in 2018 at "Hepatology"
DOI: 10.1002/hep.30091
Abstract: There is an urgent need to develop more effective therapies for hepatocellular carcinoma (HCC) because of its aggressiveness. Guadecitabine (SGI‐110) is a second‐generation DNA methyltransferase inhibitor (DNMTi), which is currently in clinical trials for HCC… read more here.
Keywords: inhibitor; hcc; therapeutic targets; sgi 110 ... See more keywords
Mast Cells: Therapeutic Targets For COVID-19 And Beyond.
Sign Up to like & getrecommendations! Published in 2021 at "IUBMB life"
DOI: 10.1002/iub.2552
Abstract: Mast cells (MCs) are innate immune cells that widely distribute throughout all tissues and express a variety of cell surface receptors. Upon activation, MCs can rapidly release a diverse array of pre-formed mediators residing within… read more here.
Keywords: targets covid; mast cells; therapeutic targets; cells therapeutic ... See more keywords
Junctophilins emerge as novel therapeutic targets
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.28405
Abstract: Junctophilins (JPs) emerge to play key role in human pathophysiology. This family includes four subtypes (JP1–4), which are differentially detected in excitable cells. Previous work demonstrated the knockout of JPs that seriously damage physiological functions… read more here.
Keywords: therapeutic targets; emerge novel; disease; jps ... See more keywords
Metastasis associated long noncoding RNAs in glioblastoma: Biomarkers and therapeutic targets.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of cellular physiology"
DOI: 10.1002/jcp.30577
Abstract: Glioblastoma (GBM) is the most aggressive, malignant, and therapeutically challenging Grade IV tumor of the brain. Although the possibility of distant metastasis is extremely rare, GBM is known to cause intracranial metastasis forming aggressive secondary lesions… read more here.
Keywords: long noncoding; glioblastoma; therapeutic targets; metastasis ... See more keywords
MAPK pathways regulation by DUSP1 in the development of osteosarcoma: Potential markers and therapeutic targets
Sign Up to like & getrecommendations! Published in 2017 at "Molecular Carcinogenesis"
DOI: 10.1002/mc.22619
Abstract: Osteosarcoma (OS) is the most frequent primary bone tumor that affect children and adolescents. This tumor is highly aggressive with high risk of metastasis and the implementation of new drugs has not been successful. The… read more here.
Keywords: dusp1; therapeutic targets; gene expression; mapk pathways ... See more keywords
Novel therapeutic targets in inflammatory bowel disease
Sign Up to like & getrecommendations! Published in 2019 at "Prescriber"
DOI: 10.1002/psb.1739
Abstract: SMAD7 antisense oligonucleotides and sphingosine‐1‐phosphate receptor modulators are new oral agents that are being investigated as potential treatments for inflammatory bowel disease (Crohn's disease and ulcerative colitis). This article reports on some of the clinical… read more here.
Keywords: bowel disease; inflammatory bowel; targets inflammatory; therapeutic targets ... See more keywords
Genomic Strategies Toward Identification of Novel Therapeutic Targets.
Sign Up to like & getrecommendations! Published in 2020 at "Handbook of experimental pharmacology"
DOI: 10.1007/164_2020_360
Abstract: Coronary artery disease, myocardial infarction, and secondary damages of the myocardium in the form of ischemic heart disease remain major causes of death in Western countries. Beyond traditional risk factors such as smoking, hypertension, dyslipidemia,… read more here.
Keywords: genomic strategies; therapeutic targets; toward identification; identification novel ... See more keywords
Aldo-Keto Reductases: Multifunctional Proteins as Therapeutic Targets in Diabetes and Inflammatory Disease.
Sign Up to like & getrecommendations! Published in 2018 at "Advances in experimental medicine and biology"
DOI: 10.1007/978-3-319-98788-0_13
Abstract: Aldose reductase (AR) is an NADPH-dependent aldo-keto reductase that has been shown to be involved in the pathogenesis of several blinding diseases such as uveitis, diabetic retinopathy (DR) and cataract. However, possible mechanisms linking the… read more here.
Keywords: aldo keto; multifunctional proteins; keto reductases; therapeutic targets ... See more keywords
Cannabidiol: pharmacology and therapeutic targets
Sign Up to like & getrecommendations! Published in 2020 at "Psychopharmacology"
DOI: 10.1007/s00213-020-05712-8
Abstract: Rationale Cannabidiol (CBD) products lacking regulatory approval are being used to self-treat a myriad of conditions and for their unsubstantiated health benefits. The scientific evidence supporting these claims largely arises not from controlled clinical trials,… read more here.
Keywords: cbd; therapeutic targets; cannabidiol pharmacology; pharmacology therapeutic ... See more keywords