The prevalence and prognosis of next‐generation therapeutic targets in metastatic castration‐resistant prostate cancer
Sign Up to like & getrecommendations! Published in 2022 at "Molecular Oncology"
DOI: 10.1002/1878-0261.13320
Abstract: The success of the PROfound, IPATential150, and TheraP trials promoted the transition from sequential treatment to therapeutic targets (TTs)‐guided precision treatment in metastatic castration‐resistant prostate cancer (mCRPC). The objective of this study was to evaluate… read more here.
Keywords: prevalence; prostate; resistant prostate; castration resistant ... See more keywords
A group of novel VEGF splice variants as alternative therapeutic targets in renal cell carcinoma.
Sign Up to like & getrecommendations! Published in 2023 at "Molecular oncology"
DOI: 10.1002/1878-0261.13401
Abstract: The efficacy of anti-angiogenic treatment by targeting VEGF/VEGF receptors in metastatic clear cell renal cell carcinoma (ccRCC) varies from patient to patient. Discovering the reasons behind this variability could lead to the identification of relevant… read more here.
Keywords: cell; renal cell; vegf; therapeutic targets ... See more keywords
The Potential Therapeutic Targets of Anlotinib in Osteosarcoma: Characterization Based on Patient‐Derived Xenografts and Next‐Generation Sequencing
Sign Up to like & getrecommendations! Published in 2024 at "Cancer Medicine"
DOI: 10.1002/cam4.70416
Abstract: The aim of this study was to analyze the potential therapeutic targets of anlotinib using the patient‐derived xenografts (PDX) and evaluate the efficacy of the combination of chemotherapy and anlotinib in osteosarcoma patients before surgery. read more here.
Keywords: therapeutic targets; patient derived; targets anlotinib; derived xenografts ... See more keywords
Integrative Epigenetic Analysis Reveals Therapeutic Targets to the DNA Methyltransferase Inhibitor Guadecitabine (SGI‐110) in Hepatocellular Carcinoma
Sign Up to like & getrecommendations! Published in 2018 at "Hepatology"
DOI: 10.1002/hep.30091
Abstract: There is an urgent need to develop more effective therapies for hepatocellular carcinoma (HCC) because of its aggressiveness. Guadecitabine (SGI‐110) is a second‐generation DNA methyltransferase inhibitor (DNMTi), which is currently in clinical trials for HCC… read more here.
Keywords: inhibitor; hcc; therapeutic targets; sgi 110 ... See more keywords
Mast Cells: Therapeutic Targets For COVID-19 And Beyond.
Sign Up to like & getrecommendations! Published in 2021 at "IUBMB life"
DOI: 10.1002/iub.2552
Abstract: Mast cells (MCs) are innate immune cells that widely distribute throughout all tissues and express a variety of cell surface receptors. Upon activation, MCs can rapidly release a diverse array of pre-formed mediators residing within… read more here.
Keywords: targets covid; mast cells; therapeutic targets; cells therapeutic ... See more keywords
Junctophilins emerge as novel therapeutic targets
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.28405
Abstract: Junctophilins (JPs) emerge to play key role in human pathophysiology. This family includes four subtypes (JP1–4), which are differentially detected in excitable cells. Previous work demonstrated the knockout of JPs that seriously damage physiological functions… read more here.
Keywords: therapeutic targets; emerge novel; disease; jps ... See more keywords
Metastasis associated long noncoding RNAs in glioblastoma: Biomarkers and therapeutic targets.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of cellular physiology"
DOI: 10.1002/jcp.30577
Abstract: Glioblastoma (GBM) is the most aggressive, malignant, and therapeutically challenging Grade IV tumor of the brain. Although the possibility of distant metastasis is extremely rare, GBM is known to cause intracranial metastasis forming aggressive secondary lesions… read more here.
Keywords: long noncoding; glioblastoma; therapeutic targets; metastasis ... See more keywords
Metabolomics‐driven discovery of therapeutic targets for cancer cachexia
Sign Up to like & getrecommendations! Published in 2024 at "Journal of Cachexia, Sarcopenia and Muscle"
DOI: 10.1002/jcsm.13465
Abstract: Cancer cachexia (CC) is a devastating metabolic syndrome characterized by skeletal muscle wasting and body weight loss, posing a significant burden on the health and survival of cancer patients. Despite ongoing efforts, effective treatments for… read more here.
Keywords: therapeutic targets; metabolism; cancer cachexia; acid metabolism ... See more keywords
MAPK pathways regulation by DUSP1 in the development of osteosarcoma: Potential markers and therapeutic targets
Sign Up to like & getrecommendations! Published in 2017 at "Molecular Carcinogenesis"
DOI: 10.1002/mc.22619
Abstract: Osteosarcoma (OS) is the most frequent primary bone tumor that affect children and adolescents. This tumor is highly aggressive with high risk of metastasis and the implementation of new drugs has not been successful. The… read more here.
Keywords: dusp1; therapeutic targets; gene expression; mapk pathways ... See more keywords
Current and Emerging Therapeutic Targets for Essential Tremor: A Critical Appraisal of Recent Preclinical and Clinical Studies
Sign Up to like & getrecommendations! Published in 2025 at "Movement Disorders Clinical Practice"
DOI: 10.1002/mdc3.70147
Abstract: Essential tremor (ET) is a common hyperkinetic movement disorder and causes significant disability. However, the response to the commonly used medications is often unsatisfactory. Hence, there is a requirement for improved treatment modalities involving novel… read more here.
Keywords: therapeutic targets; targets essential; essential tremor; emerging therapeutic ... See more keywords
Current emerging therapeutic targets and clinical investigational agents for schizophrenia: Challenges and opportunities
Sign Up to like & getrecommendations! Published in 2024 at "Medicinal Research Reviews"
DOI: 10.1002/med.22086
Abstract: Since the first discovery of antipsychotics in the 1950s, targeting dopaminergic drugs has manifested to well manage the positive symptoms of schizophrenia with limited efficacy for the negative and cognitive symptoms. In past decades, extensive… read more here.
Keywords: therapeutic targets; investigational agents; targets clinical; clinical investigational ... See more keywords