Why Therapeutic Trials Fail in Primary Tauopathies
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DOI: 10.1002/mds.29322
Abstract: Primary tauopathies are neurodegenerative diseases in which tau protein aggregates constitute the main underlying neuropathological process. Tau proteins are a group of six isomers that bind to and stabilize microtubules and play a role in… read more here.
Keywords: fail primary; disease; trials fail; therapeutic trials ... See more keywords
Recommendations for the design of therapeutic trials for neonatal seizures
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DOI: 10.1038/s41390-018-0242-2
Abstract: Although seizures have a higher incidence in neonates than any other age group and are associated with significant mortality and neurodevelopmental disability, treatment is largely guided by physician preference and tradition, due to a lack… read more here.
Keywords: group; trials neonatal; neonatal seizures; design therapeutic ... See more keywords
Evaluating Primary Endpoints for COVID-19 Therapeutic Trials to Assess Recovery
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DOI: 10.1164/rccm.202112-2836oc
Abstract: Rationale Uncertainty regarding the natural history of coronavirus disease (COVID-19) led to difficulty in efficacy endpoint selection for therapeutic trials. Capturing outcomes that occur after hospital discharge may improve assessment of clinical recovery among hospitalized… read more here.
Keywords: patients hospitalized; hospital discharge; therapeutic trials; approach ... See more keywords
Therapeutic trials for long COVID-19: A call to action from the interventions taskforce of the RECOVER initiative
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2023.1129459
Abstract: Although most individuals recover from acute SARS-CoV-2 infection, a significant number continue to suffer from Post-Acute Sequelae of SARS-CoV-2 (PASC), including the unexplained symptoms that are frequently referred to as long COVID, which could last… read more here.
Keywords: recover initiative; long covid; covid call; therapeutic trials ... See more keywords