Therapeutic vaccination against leukaemia via the sustained release of co-encapsulated anti-PD-1 and a leukaemia-associated antigen.
Sign Up to like & getrecommendations! Published in 2020 at "Nature biomedical engineering"
DOI: 10.1038/s41551-020-00624-6
Abstract: Therapeutic leukaemia vaccines have shown modest potency. Here, we show that the co-encapsulation of a leukaemia-associated epitope peptide highly expressed in leukaemia patients and of the immune checkpoint inhibitor anti-programmed-cell-death-protein-1 (anti-PD-1) in degradable poly(lactic acid)… read more here.
Keywords: leukaemia associated; therapeutic vaccination; sustained release; vaccination leukaemia ... See more keywords
Abstract 697: Extracellular vesicles (EV) - mediators of therapeutic vaccination? In vivo and in vitro characterization of EVs generated after infection of human and murine cells with therapeutic poxviruses
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-697
Abstract: Virus-based therapies show promise in inducing systemic anti-tumor immunity. Over the past years, modified poxviruses were developed to induce a sustained antitumoral immune response. Several studies confirm this hypothesis and report induction of T cell… read more here.
Keywords: infection human; infection; evs; murine ... See more keywords
Preclinical evaluation of NF-κB-triggered dendritic cells expressing the viral oncogenic driver of Merkel cell carcinoma for therapeutic vaccination
Sign Up to like & getrecommendations! Published in 2017 at "Therapeutic Advances in Medical Oncology"
DOI: 10.1177/1758834017712630
Abstract: Background: Merkel cell carcinoma (MCC) is a rare but very aggressive skin tumor that develops after integration of a truncated form of the large T-antigen (truncLT) of the Merkel cell polyomavirus (MCV) into the host’s… read more here.
Keywords: merkel cell; cell; therapeutic vaccination; dcs ... See more keywords
Eradication of HIV-1 latent reservoirs through therapeutic vaccination
Sign Up to like & getrecommendations! Published in 2017 at "AIDS Research and Therapy"
DOI: 10.1186/s12981-017-0177-4
Abstract: Despite the significant success of combination anti-retroviral therapy to reduce HIV viremia and save lives, HIV-1 infection remains a lifelong infection that must be appropriately managed. Advances in the understanding of the HIV infection process… read more here.
Keywords: hiv latent; eradication hiv; therapeutic vaccination; hiv ... See more keywords
IL-10 expression defines an immunosuppressive dendritic cell population induced by antitumor therapeutic vaccination
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DOI: 10.18632/oncotarget.13736
Abstract: Vaccination induces immunostimulatory signals that are often accompanied by regulatory mechanisms such as IL-10, which control T-cell activation and inhibit vaccine-dependent antitumor therapeutic effect. Here we characterized IL-10-producing cells in different tumor models treated with… read more here.
Keywords: antitumor therapeutic; therapeutic vaccination; expression; vaccination ... See more keywords
Rationale for an Association Between PD1 Checkpoint Inhibition and Therapeutic Vaccination Against HIV
Sign Up to like & getrecommendations! Published in 2018 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2018.02447
Abstract: The pathogenesis of HIV immunodeficiency is mainly dependent on the cytopatic effects exerted by the virus against infected CD4+ T cells. However, CD4+ T cell loss cannot be the only pathogenic factor since severe opportunistic… read more here.
Keywords: pd1; therapeutic vaccination; hiv; checkpoint inhibition ... See more keywords
Ribonucleic Acid Engineering of Dendritic Cells for Therapeutic Vaccination: Ready ‘N Able to Improve Clinical Outcome?
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DOI: 10.3390/cancers12020299
Abstract: Targeting and exploiting the immune system has become a valid alternative to conventional options for treating cancer and infectious disease. Dendritic cells (DCs) take a central place given their role as key orchestrators of immunity.… read more here.
Keywords: engineering; ribonucleic acid; therapeutic vaccination; acid engineering ... See more keywords
Therapeutic Vaccination in Head and Neck Squamous Cell Carcinoma—A Review
Sign Up to like & getrecommendations! Published in 2023 at "Vaccines"
DOI: 10.3390/vaccines11030634
Abstract: Therapeutic vaccination is one of the most effective immunotherapeutic approaches, second only to immune checkpoint inhibitors (ICIs), which have already been approved for clinical use. Head and neck squamous cell carcinomas (HNSCCs) are heterogenous epithelial… read more here.
Keywords: head neck; vaccination; squamous cell; therapeutic vaccination ... See more keywords