Funding Sources of Therapeutic and Vaccine Clinical Trials for COVID-19 vs Non–COVID-19 Indications, 2020-2021
Sign Up to like & getrecommendations! Published in 2022 at "JAMA Network Open"
DOI: 10.1001/jamanetworkopen.2022.26892
Abstract: Key Points Question What were the major sources of funding for clinical trials focused on the development of therapeutics and vaccines against COVID-19 between January 1, 2020, and August 31, 2021? Findings In this cross-sectional… read more here.
Keywords: therapeutic vaccine; clinical trials; trials covid; sources therapeutic ... See more keywords
Exploration of Antigen Induced CaCO3 Nanoparticles for Therapeutic Vaccine.
Sign Up to like & getrecommendations! Published in 2018 at "Small"
DOI: 10.1002/smll.201704272
Abstract: Therapeutic vaccines possess particular advantages and show promising potential to combat burdening diseases, such as acquired immunodeficiency syndrome, hepatitis, and even cancers. An efficient therapeutic vaccine would strengthen the immune system and eventually eliminate target… read more here.
Keywords: exploration antigen; therapeutic vaccine; caco3 nanoparticles; antigen ... See more keywords
Advances in therapeutic and vaccine targets for Cryptosporidium: challenges and possible mitigation strategies.
Sign Up to like & getrecommendations! Published in 2021 at "Acta tropica"
DOI: 10.1016/j.actatropica.2021.106273
Abstract: Cryptosporidium is known to be the second most common diarrheal pathogen in children, causing potentially fatal diarrhea and associated with long-term growth stunting and cognitive deficits. The only Food and Drug Administration-approved treatment for cryptosporidiosis… read more here.
Keywords: drug; advances therapeutic; targets cryptosporidium; vaccine targets ... See more keywords
Therapeutic vaccine strategies to induce tumor-specific T-cell responses
Sign Up to like & getrecommendations! Published in 2019 at "Bone Marrow Transplantation"
DOI: 10.1038/s41409-019-0619-9
Abstract: Haploidentical stem cell transplantation is increasingly used worldwide as an alternative donor transplantation method. Although novel preparative regimens and T-cell deletion techniques have improved engraftment rates and viral safety, relapses of the underlying leukemia/lymphoma are… read more here.
Keywords: vaccine strategies; cell responses; therapeutic vaccine; tumor specific ... See more keywords
Oxidative stress implications for therapeutic vaccine development against Chagas disease.
Sign Up to like & getrecommendations! Published in 2021 at "Expert review of vaccines"
DOI: 10.1080/14760584.2021.1969230
Abstract: INTRODUCTION Pathogenesis of Chagas disease (CD) caused by the protozoan parasite Trypanosoma cruzi (T. cruzi) involves chronic oxidative and inflammatory stress. In this review, we discuss the research efforts in therapeutic vaccine development to date… read more here.
Keywords: therapeutic vaccine; stress; vaccine; chagas disease ... See more keywords
Intranasal therapeutic vaccine containing HBsAg and HBcAg for patients with chronic hepatitis B; 18 months follow‐up results of phase IIa clinical study
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DOI: 10.1111/hepr.13851
Abstract: HBsAg loss with anti‐HBs acquisition is considered a functional cure and ideal treatment goal for patients with CHB. Our group have reported the efficacy of therapeutic vaccine with HBsAg and HBcAg (NASVAC) by intranasal and… read more here.
Keywords: intranasal therapeutic; hbsag hbcag; study; therapeutic vaccine ... See more keywords
Immunomodulation to enhance the efficacy of an HPV therapeutic vaccine
Sign Up to like & getrecommendations! Published in 2020 at "Journal for Immunotherapy of Cancer"
DOI: 10.1136/jitc-2020-000612
Abstract: Background While prophylactic human papillomavirus (HPV) vaccines will certainly reduce the incidence of HPV-associated cancers, these malignancies remain a major health issue. PDS0101 is a liposomal-based HPV therapeutic vaccine consisting of the immune activating cationic… read more here.
Keywords: immunomodulation enhance; therapeutic vaccine; antitumor effects; hpv therapeutic ... See more keywords
Expression optimization of a cell membrane-penetrating human papillomavirus type 16 therapeutic vaccine candidate in Nicotiana benthamiana
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DOI: 10.1371/journal.pone.0183177
Abstract: High-risk human papillomaviruses (hr-HPVs) cause cervical cancer, the fourth most common cancer in women worldwide. A HPV-16 candidate therapeutic vaccine, LALF32-51-E7, was developed by fusing a modified E7 protein to a bacterial cell-penetrating peptide (LALF):… read more here.
Keywords: candidate; therapeutic vaccine; expression; expression optimization ... See more keywords
Therapeutic vaccine to cure large mouse hepatocellular carcinomas.
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DOI: 10.18632/oncotarget.19367
Abstract: Hepatocellular carcinoma (HCC) is one of the most common malignancies worldwide with limited therapeutic options. Here we report the development of a therapeutic vaccination regimen (shortened as 'TheraVac') consisting of intratumoral delivery of high-mobility group… read more here.
Keywords: hepa1; large mouse; therapeutic vaccine; cure large ... See more keywords
Cruzipain and Its Physiological Inhibitor, Chagasin, as a DNA-Based Therapeutic Vaccine Against Trypanosoma cruzi
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2020.565142
Abstract: Chagas disease caused by the protozoan parasite Trypanosoma cruzi is endemic in 21 Latin American countries and the southern United States and now is spreading into several other countries due to migration. Despite the efforts… read more here.
Keywords: vaccine; infection; trypanosoma cruzi; therapeutic vaccine ... See more keywords
A Component-Resolved Therapeutic Vaccine for Cockroach Allergy Made of Per a 9 and Transforming Growth Factor-β Homologue, an Immunosuppressive Protein of Brugia malayi
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2021.676558
Abstract: Allergen-specific-immunotherapy (ASIT) can cause long-term resolution of allergic diseases, reduces drug use and chances of new allergen sensitization. Nevertheless, therapeutic vaccine and data on ASIT efficacy for cockroach (CR) allergy are relatively scarce. In this… read more here.
Keywords: protein brugia; therapeutic vaccine; allergy; cockroach allergy ... See more keywords