Proteogenomic Characterization Reveals Therapeutic Vulnerabilities in Lung Adenocarcinoma
Sign Up to like & getrecommendations! Published in 2020 at "Cell"
DOI: 10.1016/j.cell.2020.06.013
Abstract: To explore the biology of lung adenocarcinoma (LUAD) and identify new therapeutic opportunities, we performed comprehensive proteogenomic characterization of 110 tumors and 101 matched normal adjacent tissues (NATs) incorporating genomics, epigenomics, deep-scale proteomics, phosphoproteomics, and… read more here.
Keywords: lung adenocarcinoma; characterization reveals; therapeutic vulnerabilities; proteogenomic characterization ... See more keywords
Somatic mutation subtypes of lung adenocarcinoma in East Asian reveal divergent biological characteristics and therapeutic vulnerabilities
Sign Up to like & getrecommendations! Published in 2021 at "iScience"
DOI: 10.1016/j.isci.2021.102522
Abstract: Summary Lung adenocarcinoma (LUAD) patients in East Asia predominantly harbor oncogenic EGFR mutations. However, there remains a limited understanding of the biological characteristics and therapeutic vulnerabilities of the concurrent mutations of EGFR and other genes… read more here.
Keywords: lung adenocarcinoma; mutation; characteristics therapeutic; therapeutic vulnerabilities ... See more keywords
Molecular characteristics and therapeutic vulnerabilities across paediatric solid tumours
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DOI: 10.1038/s41568-019-0169-x
Abstract: The spectrum of tumours arising in childhood is fundamentally different from that seen in adults, and they are known to be divergent from adult malignancies in terms of cellular origins, epidemiology, genetic complexity, driver mutations… read more here.
Keywords: characteristics therapeutic; therapeutic vulnerabilities; vulnerabilities across; paediatric solid ... See more keywords
EPCO-36. GENOMIC INSTABILITY AND TRANSCRIPTOMIC SIGNATURES UNDERLYING EPIGENETIC MENINGIOMA SUBGROUPS REVEALS MECHANISMS OF IMMUNE INFILTRATION AND THERAPEUTIC VULNERABILITIES
Sign Up to like & getrecommendations! Published in 2020 at "Neuro-oncology"
DOI: 10.1093/neuonc/noaa215.315
Abstract: Meningioma treatments are limited due to incomplete understanding of meningioma biology. To address this, we performed multiplatform molecular profiling on 565 meningiomas with comprehensive clinical data to define genomic drivers and identify therapeutic vulnerabilities. DNA… read more here.
Keywords: meningiomas; genomic instability; therapeutic vulnerabilities; meningioma ... See more keywords
HGG-32. UNCOVERING THERAPEUTIC VULNERABILITIES IN MISMATCH REPAIR-DEFICIENT GLIOMAS
Sign Up to like & getrecommendations! Published in 2020 at "Neuro-Oncology"
DOI: 10.1093/neuonc/noaa222.314
Abstract: Abstract INTRODUCTION We have observed that approximately 26% of recurrent gliomas acquire hypermutation following treatment with temozolomide (TMZ). Intriguingly, 91% of these tumors harbor mutations in mismatch repair (MMR) genes. Strategies to target MMR-deficient gliomas… read more here.
Keywords: deficient gliomas; therapeutic vulnerabilities; gliomas; mismatch repair ... See more keywords
Epigenomic Reordering Induced by Polycomb Loss Drives Oncogenesis but Leads to Therapeutic Vulnerabilities in Malignant Peripheral Nerve Sheath Tumors.
Sign Up to like & getrecommendations! Published in 2019 at "Cancer research"
DOI: 10.1158/0008-5472.can-18-3704
Abstract: Malignant peripheral nerve sheath tumor (MPNST) is an aggressive sarcoma with recurrent loss-of-function alterations in polycomb-repressive complex 2 (PRC2), a histone-modifying complex involved in transcriptional silencing. To understand the role of PRC2 loss in pathogenesis… read more here.
Keywords: therapeutic vulnerabilities; malignant peripheral; loss; nerve sheath ... See more keywords
Identifying therapeutic vulnerabilities in lung cancer: application of a chemistry-first approach.
Sign Up to like & getrecommendations! Published in 2018 at "Translational lung cancer research"
DOI: 10.21037/tlcr.2018.09.10
Abstract: In the last three decades, 5-year relative survival rates for lung cancer improved slightly, from 14.3%, 15.5%, and 18.4% (1). One of the reasons for these dismal survival rates is that most patients present with… read more here.
Keywords: identifying therapeutic; vulnerabilities lung; therapeutic vulnerabilities; chemistry ... See more keywords
SMARCB1-Deficient Cancers: Novel Molecular Insights and Therapeutic Vulnerabilities
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DOI: 10.3390/cancers14153645
Abstract: Simple Summary Loss of SMARCB1 has been identified as the sole mutation in a number of rare pediatric and adult cancers, most of which have a poor prognosis despite intensive therapies including surgery, radiation, and… read more here.
Keywords: loss smarcb1; smarcb1 deficient; deficient; tumor ... See more keywords
Therapeutic Vulnerabilities in FLT3-Mutant AML Unmasked by Palbociclib
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DOI: 10.3390/ijms19123987
Abstract: While significant progress has been made in the treatment of acute myeloid leukemia (AML), not all patients can be cured. Mutated in about 1/3 of de novo AML, the FLT3 receptor tyrosine kinase is an… read more here.
Keywords: therapeutic vulnerabilities; flt3; flt3 itd; aml ... See more keywords
Genome maintenance in retinoblastoma: Implications for therapeutic vulnerabilities
Sign Up to like & getrecommendations! Published in 2022 at "Oncology Letters"
DOI: 10.3892/ol.2022.13312
Abstract: Retinoblastoma (RB) is a pediatric ocular malignancy that is initiated mostly by biallelic inactivation of the RB transcriptional corepressor 1 (RB1) tumor suppressor gene in the developing retina. Unlike the prevailing prediction based on multiple… read more here.
Keywords: maintenance; maintenance retinoblastoma; genome maintenance; maintenance mechanisms ... See more keywords