Intraoperative clinical testing overestimates the therapeutic window of the permanent DBS electrode in the subthalamic nucleus
Sign Up to like & getrecommendations! Published in 2017 at "Acta Neurochirurgica"
DOI: 10.1007/s00701-017-3255-4
Abstract: BackgroundIntraoperative test stimulation is established to optimize target localization in STN DBS, but requires a time-consuming awake surgery in off-medication state. The aim of this study was to compare the thresholds of stimulation-induced effects of… read more here.
Keywords: stimulation; therapeutic window; dbs; test stimulation ... See more keywords
Vitamin C supplementation expands the therapeutic window of BETi for triple negative breast cancer
Sign Up to like & getrecommendations! Published in 2019 at "EBioMedicine"
DOI: 10.1016/j.ebiom.2019.04.006
Abstract: Background Bromodomain and extra-terminal inhibitors (BETi) have shown efficacy for the treatment of aggressive triple negative breast cancer (TNBC). However, BETi are plagued by a narrow therapeutic window as manifested by severe toxicities at effective… read more here.
Keywords: beti; therapeutic window; cancer; vitamin ... See more keywords
Utilization of redox modulating small molecules that selectively act as pro-oxidants in cancer cells to open a therapeutic window for improving cancer therapy
Sign Up to like & getrecommendations! Published in 2021 at "Redox Biology"
DOI: 10.1016/j.redox.2021.101864
Abstract: There is a rapidly growing body of literature supporting the notion that differential oxidative metabolism in cancer versus normal cells represents a metabolic frailty that can be exploited to open a therapeutic window into cancer… read more here.
Keywords: cancer; open therapeutic; therapeutic window; cancer therapy ... See more keywords
Genetically encoded stealth nanoparticles of a zwitterionic polypeptide-paclitaxel conjugate have a wider therapeutic window than Abraxane in multiple tumor models.
Sign Up to like & getrecommendations! Published in 2020 at "Nano letters"
DOI: 10.1021/acs.nanolett.9b05094
Abstract: Small-molecule therapeutics demonstrate sub-optimal pharmacokinetics and bioavailability due to their hydrophobicity and size. One way to overcome these limitations-and improve their efficacy-is to use "stealth" macromolecular carriers that evade uptake by the reticuloendothelial system. Although… read more here.
Keywords: therapeutic window; stealth; window abraxane; wider therapeutic ... See more keywords
Balancing the interplay between ligand ejection and therapeutic window light absorption in ruthenium polypyridyl complexes.
Sign Up to like & getrecommendations! Published in 2022 at "Dalton transactions"
DOI: 10.1039/d2dt01237e
Abstract: Ruthenium polypyridyl complexes have gained significant interest as photochemotherapies (PCTs) where their excited-state properties play a critical role in the photo-cytotoxicity mechanism and efficacy. Herein we report a systematic electrochemical, spectrochemical, and photophysical analysis of… read more here.
Keywords: ruthenium polypyridyl; polypyridyl; ligand; therapeutic window ... See more keywords
Therapeutic window of opportunity in the acute uveitic phase of Vogt–Koyanagi–Harada disease: Prevention of late autoimmune complications by early intervention
Sign Up to like & getrecommendations! Published in 2022 at "Acta Ophthalmologica"
DOI: 10.1111/aos.15254
Abstract: To determine relationship between timing of treatment initiation and disease outcomes and whether a therapeutic window of opportunity exists in initial‐onset acute uveitis associated with Vogt–Koyanagi–Harada disease. read more here.
Keywords: window opportunity; disease; harada disease; koyanagi harada ... See more keywords
Optimizing the Therapeutic Window of Targeted Drugs in Oncology: Potency‐Guided First‐in‐Human Studies
Sign Up to like & getrecommendations! Published in 2020 at "Clinical and Translational Science"
DOI: 10.1111/cts.12902
Abstract: Many targeted therapies are administered at or near the maximum tolerated dose (MTD). With the advent of precision medicine, a larger therapeutic window is expected. Therefore, dose optimization will require a new approach to early… read more here.
Keywords: potency; therapeutic window; css; first human ... See more keywords
Early Collateral Recruitment After Stroke in Infants and Adults.
Sign Up to like & getrecommendations! Published in 2019 at "Stroke"
DOI: 10.1161/strokeaha.119.025353
Abstract: Stroke is a disorder affecting all age groups, particularly those at opposite ends of the age spectrum. At the perinatal period, arterial ischemic stroke (AIS) occurs in 1/2800 to 1/5000 live births. Groups at risk… read more here.
Keywords: occlusion; therapeutic window; recruitment; artery ... See more keywords
Oxygen therapeutic window induced by myo-inositol trispyrophosphate (ITPP)–Local pO2 study in murine tumors
Sign Up to like & getrecommendations! Published in 2023 at "PLOS ONE"
DOI: 10.1371/journal.pone.0285318
Abstract: Hypoxia, an inevitable feature of locally advanced solid tumors, has been known as an adverse prognostic factor, a driver of an aggressive phenotype, and an unfavorable factor in therapies. Myo-inositol trispyrophosphate (ITPP) is a hemoglobin… read more here.
Keywords: myo inositol; po2; itpp; tumor ... See more keywords
Expanding the Therapeutic Window of EGFR-Targeted PE24 Immunotoxin for EGFR-Overexpressing Cancers by Tailoring the EGFR Binding Affinity
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms232415820
Abstract: Immunotoxins (ITs), which are toxin-fused tumor antigen-specific antibody chimeric proteins, have been developed to selectively kill targeted cancer cells. The epidermal growth factor receptor (EGFR) is an attractive target for the development of anti-EGFR ITs… read more here.
Keywords: anti egfr; affinity; egfr; tumor ... See more keywords
Manuka Honey Reduces NETosis on an Electrospun Template Within a Therapeutic Window
Sign Up to like & getrecommendations! Published in 2020 at "Polymers"
DOI: 10.3390/polym12061430
Abstract: Manuka honey, a topical wound treatment used to eradicate bacteria, resolve inflammation, and promote wound healing, is a focus in the tissue engineering community as a tissue template additive. However, its effect on neutrophil extracellular… read more here.
Keywords: template; honey; netosis; therapeutic window ... See more keywords