Senescence as a therapeutically relevant response to CDK4/6 inhibitors
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DOI: 10.1038/s41388-020-1354-9
Abstract: Cyclin-dependent kinases 4 and 6 (CDK4/6) phosphorylate and inhibit retinoblastoma (RB) family proteins. Hyperphosphorylated RB releases E2F transcription factors, activating a transcriptional program that initiates S phase. Due to the critical role that this pathway… read more here.
Keywords: response; senescence therapeutically; senescence; therapeutically relevant ... See more keywords
Abstract 3078: Tesetaxel, a novel, oral taxane, crosses intact blood-brain barrier (BBB) at therapeutically relevant concentrations
Sign Up to like & getrecommendations! Published in 2019 at "Cancer Research"
DOI: 10.1158/1538-7445.sabcs18-3078
Abstract: Background: Central nervous system (CNS) metastases in cancers such as breast and lung cancer are common and associated with poor outcomes. The taxanes paclitaxel (P) and docetaxel (D) do not significantly cross the BBB (brain… read more here.
Keywords: taxane; cancer; tesetaxel novel; therapeutically relevant ... See more keywords
Nanobiotechnology with Therapeutically Relevant Macromolecules from Animal Venoms: Venoms, Toxins, and Antimicrobial Peptides
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DOI: 10.3390/pharmaceutics14050891
Abstract: Some diseases of uncontrolled proliferation such as cancer, as well as infectious diseases, are the main cause of death in the world, and their causative agents have rapidly developed resistance to the various existing treatments,… read more here.
Keywords: nanotechnology; macromolecules animal; relevant macromolecules; animal venoms ... See more keywords