Ischemic Microenvironment-Responsive Therapeutics for Cardiovascular Diseases.
Sign Up to like & getrecommendations! Published in 2021 at "Advanced materials"
DOI: 10.1002/adma.202105348
Abstract: Cardiovascular diseases caused by ischemia are attracting considerable attention owing to its high morbidity and mortality worldwide. Although numerous agents with cardioprotective benefits have been identified, their clinical outcomes are hampered by their low bioavailability,… read more here.
Keywords: ischemic microenvironment; microenvironment responsive; responsive therapeutics; cardiovascular diseases ... See more keywords
MicroRNA-based therapeutics in cardiovascular disease: screening and delivery to the target.
Sign Up to like & getrecommendations! Published in 2018 at "Biochemical Society transactions"
DOI: 10.1042/bst20170037
Abstract: MicroRNAs (miRNAs) are small non-coding RNAs of ∼22 nucleotides, which have increasingly been recognized as potent post-transcriptional regulators of gene expression. MiRNA targeting is defined by the complementarities between positions 2-8 of miRNA 5'-end with… read more here.
Keywords: delivery; target; microrna based; therapeutics cardiovascular ... See more keywords
Small non-coding RNA therapeutics for cardiovascular disease
Sign Up to like & getrecommendations! Published in 2022 at "European Heart Journal"
DOI: 10.1093/eurheartj/ehac463
Abstract: Abstract Novel bio-therapeutic agents that harness the properties of small, non-coding nucleic acids hold great promise for clinical applications. These include antisense oligonucleotides that inhibit messenger RNAs, microRNAs (miRNAs), or long non-coding RNAs; positive effectors… read more here.
Keywords: therapeutics cardiovascular; non coding; disease; rna therapeutics ... See more keywords
Preclinical and Clinical Development of Noncoding RNA Therapeutics for Cardiovascular Disease
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DOI: 10.1161/circresaha.119.315856
Abstract: RNA modulation has become a promising therapeutic approach for the treatment of several types of disease. The emerging field of noncoding RNA-based therapies has now come to the attention of cardiovascular research, in which it… read more here.
Keywords: cardiovascular disease; rna based; development noncoding; therapeutics cardiovascular ... See more keywords
Inflammatory Burden and Immunomodulative Therapeutics of Cardiovascular Diseases
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23020804
Abstract: Phenotyping cardiovascular illness and recognising heterogeneities within are pivotal in the contemporary era. Besides traditional risk factors, accumulated evidence suggested that a high inflammatory burden has emerged as a key characteristic modulating both the pathogenesis… read more here.
Keywords: therapeutics cardiovascular; burden immunomodulative; cardiovascular diseases; inflammatory burden ... See more keywords