Single Doses of Antibody Drug Conjugates (ADCs) Targeted to CD117 or CD45 Have Potent In Vivo Anti-Leukemia Activity and Survival Benefit in Patient Derived AML Models
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DOI: 10.1182/blood-2018-99-112726
Abstract: Background. Allogeneic bone marrow transplant (BMT) is a potentially curative approach in patients with refractory or high risk hematologic malignancies, such as acute myeloid leukemia (AML) and myelodysplastic syndromes (MDS). Prior to transplant, patients are… read more here.
Keywords: therapeutics employment; magenta therapeutics; equity ownership; employment equity ... See more keywords
A Phase 1/2 Trial of Investigational Spk-8011 in Hemophilia a Demonstrates Durable Expression and Prevention of Bleeds
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DOI: 10.1182/blood-2018-99-115495
Abstract: Gene transfer for hemophilia A offers the potential for a one-time disease altering treatment, eliminating the risk of bleeds while freeing patients from the burden of lifelong chronic therapy. SPK-8011 consists of a bioengineered AAV… read more here.
Keywords: spark; therapeutics employment; spark therapeutics; research funding ... See more keywords
Targeted Degradation of IRAK4 Protein Via Heterobifunctional Small Molecules for Treatment of MYD88 Mutant Lymphoma
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DOI: 10.1182/blood-2018-99-120148
Abstract: Recurrent mutations in the scaffolding protein MYD88 are present in 30-40% of activated B cell diffuse lymphocytic B cell lymphoma (ABC-DLBCL)(Ngo et al. Nature 2011). MYD88 links activated interleukin 1 receptor (IL1R) and Toll-like receptors… read more here.
Keywords: kymera therapeutics; therapeutics employment; equity ownership; employment equity ... See more keywords
A Single Dose of CD117 Antibody Drug Conjugate Enables Autologous Gene-Modified Hematopoietic Stem Cell Transplant (Gene Therapy) in Nonhuman Primates
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DOI: 10.1182/blood-2019-125968
Abstract: Autologous hematopoietic stem cell transplantation (Auto-HSCT) with gene-modification techniques represents a potential cure for multiple genetic blood diseases. Despite its broad curative potential, auto-gene modified HSCT is currently limited due to morbidity/mortality from cytotoxic chemotherapy-based… read more here.
Keywords: equity ownership; employment equity; therapeutics employment; magenta therapeutics ... See more keywords
NKTR-255, a Polymer-Conjugated IL-15 Enhances Antibody-Dependent Cellular Cytotoxicity Mediated By NK Cells in a B Cell Lymphoma Model
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DOI: 10.1182/blood-2019-127771
Abstract: Background IL-15 is a cytokine that activates and provides survival benefit to T and NK cells and has great potential as an immunotherapeutic agent for the treatment of cancer. Exploiting the therapeutic value of native… read more here.
Keywords: nktr 255; equity ownership; nektar therapeutics; treatment ... See more keywords
PTC299 Is a Novel DHODH Inhibitor That Modulates VEGFA mRNA Translation and Inhibits Proliferation of a Broad Range of Leukemia Cells
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DOI: 10.1182/blood.v130.suppl_1.1371.1371
Abstract: PTC299 was identified in a phenotypic high through put screen as an inhibitor of VEGFA mRNA translation and had been in clinical development for solid tumors. Here we demonstrate that PTC299 inhibits dihydroorotate dehydrogenase (DHODH),… read more here.
Keywords: ptc therapeutics; therapeutics employment; translation; ptc299 ... See more keywords