Protein therapeutics and their lessons: Expect the unexpected when inhibiting the multi‐protein cascade of the complement system
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DOI: 10.1111/imr.13164
Abstract: Over a century after the discovery of the complement system, the first complement therapeutic was approved for the treatment of paroxysmal nocturnal hemoglobinuria (PNH). It was a long‐acting monoclonal antibody (aka 5G1‐1, 5G1.1, h5G1.1, and… read more here.
Keywords: complement; therapeutics lessons; complement cascade; complement system ... See more keywords