Antibody Therapies Targeting Complex Membrane Proteins
Sign Up to like & getrecommendations! Published in 2021 at "Engineering"
DOI: 10.1016/j.eng.2020.11.013
Abstract: Abstract In analyses of protein families that may serve as drug targets, membrane-associated G-protein-coupled receptors (GPCRs) dominate, followed by ion channels, transporters, and—to a lesser extent—membrane-bound enzymes. However, various challenges put such membrane proteins among… read more here.
Keywords: membrane proteins; antibody therapies; membrane; therapies targeting ... See more keywords
Cardiovascular Therapies Targeting Left Atrial Appendage.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of the American College of Cardiology"
DOI: 10.1016/j.jacc.2018.05.048
Abstract: Left atrial appendage (LAA) closure has evolved as an effective strategy for stroke prevention in patients with atrial fibrillation who are considered suitable for oral anticoagulation. There is strong evidence based on randomized clinical trials… read more here.
Keywords: targeting left; cardiovascular therapies; atrial appendage; left atrial ... See more keywords
Novel Therapies Targeting Cardioprotection and Regeneration.
Sign Up to like & getrecommendations! Published in 2017 at "Current pharmaceutical design"
DOI: 10.2174/1381612823666170112122637
Abstract: Cardiovascular disease is the leading cause of death worldwide. The heart is susceptible to pathologies that impact the myocardium directly, such as myocardial infarction and consequent heart failure, as well as conditions with indirect cardiac… read more here.
Keywords: death; regeneration; cardioprotection regeneration; novel therapies ... See more keywords
Neuroinflammation in retinitis pigmentosa: Therapies targeting the innate immune system
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.1059947
Abstract: Retinitis pigmentosa (RP) is an important cause of irreversible blindness worldwide and lacks effective treatment strategies. Although mutations are the primary cause of RP, research over the past decades has shown that neuroinflammation is an… read more here.
Keywords: therapies targeting; innate immune; retinitis pigmentosa;
New Insight into Therapies Targeting Angiogenesis in Hepatocellular Carcinoma
Sign Up to like & getrecommendations! Published in 2019 at "Cancers"
DOI: 10.3390/cancers11081086
Abstract: Hepatocellular carcinoma (HCC) is a malignancy characterized by neoangiogenesis that is determined by an augmented production of proangiogenesis factors by tumor and adjacent cells. This unbalanced angiogenesis process is a key feature of HCC carcinogenesis… read more here.
Keywords: hepatocellular carcinoma; insight therapies; angiogenesis; treatment ... See more keywords
Current Status of 68Ga-Pentixafor in Solid Tumours
Sign Up to like & getrecommendations! Published in 2022 at "Diagnostics"
DOI: 10.3390/diagnostics12092135
Abstract: Chemokine receptor CXCR4 is overexpressed in neoplasms and its expression is related to tumour invasion, metastasis and aggressiveness. 68Ga-Pentixafor is used to non-invasively image the expression of CXCR4 in tumours and has been widely used… read more here.
Keywords: solid tumours; 68ga pentixafor; pentixafor solid; targeting cxcr4 ... See more keywords