Polθ Inhibition: An Anticancer Therapy for HR-Deficient Tumours
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DOI: 10.3390/ijms24010319
Abstract: DNA polymerase theta (Polθ)-mediated end joining (TMEJ) is, along with homologous recombination (HR) and non-homologous end-joining (NHEJ), one of the most important mechanisms repairing potentially lethal DNA double-strand breaks (DSBs). Polθ is becoming a new… read more here.
Keywords: inhibition; therapy deficient; pol inhibition; anticancer therapy ... See more keywords