Real-world analyses of therapy discontinuation of checkpoint inhibitors in metastatic melanoma patients
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DOI: 10.1038/s41598-020-71788-z
Abstract: The ‘real-world’ patient population of metastatic melanoma is not fully represented in clinical trials investigating checkpoint inhibitors. We described therapy discontinuation in an unselected population-based cohort of adults with metastatic melanoma who started therapy with… read more here.
Keywords: metastatic melanoma; therapy discontinuation; discontinuation; checkpoint inhibitors ... See more keywords
IBD Flare in the COVID-19 Pandemic: Therapy Discontinuation Is to Blame
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DOI: 10.1093/ibd/izac173
Abstract: This prospective case-control study investigated the impact of severe acute respiratory syndrome coronavirus 2 infection on inflammatory bowel disease course and looked for risk factors associated with flares. In the severe acute respiratory syndrome coronavirus… read more here.
Keywords: inflammatory bowel; therapy discontinuation; therapy; ibd flare ... See more keywords
Hepatitis B virus–specific T cells associate with viral control upon nucleos(t)ide-analogue therapy discontinuation
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DOI: 10.1172/jci92812
Abstract: BACKGROUND. The clinical management of chronic hepatitis B virus (HBV) patients is based exclusively on virological parameters that cannot independently determine in which patients nucleos(t)ide-analogue (NUC) therapy can be safely discontinued. NUCs efficiently suppress viral… read more here.
Keywords: hbv; specific cells; discontinuation; hepatitis virus ... See more keywords
Cerebral Toxoplasmosis, CMV and Bacterial Pneumonia with Decreasing CD4+ T-Cell Count as Results of Antiretroviral Therapy Discontinuation—A Case Report
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DOI: 10.3390/pathogens10040497
Abstract: Cerebral toxoplasmosis occurs mainly in immunocompromised hosts as a reactivation of latent Toxoplasma gondii infection. In the diagnostic process, magnetic resonance imaging (MRI), serum testing, and biopsy are used. We describe a case of a… read more here.
Keywords: antiretroviral therapy; cerebral toxoplasmosis; cd4 cell; therapy discontinuation ... See more keywords