Extracorporal Shock Waves Activate Migration, Proliferation and Inflammatory Pathways in Fibroblasts and Keratinocytes, and Improve Wound Healing in an Open-Label, Single-Arm Study in Patients with Therapy-Refractory Chronic Leg Ulcers
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DOI: 10.1159/000460503
Abstract: Background/Aims: Chronic leg ulcers (CLUs) are globally a major cause of morbidity and mortality with increasing prevalence. Their treatment is highly challenging, and many conservative, surgical or advanced therapies have been suggested, but with little… read more here.
Keywords: wound healing; leg ulcers; proliferation; therapy refractory ... See more keywords
Infliximab therapy in refractory sarcoidosis: a multicenter real-world analysis
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DOI: 10.1186/s12931-022-01971-5
Abstract: Background Infliximab is a monoclonal antibody that binds and neutralizes circulating tumor necrosis factor-alpha, a key inflammatory cytokine in the pathophysiology of sarcoidosis. Despite the paucity of randomized clinical trials, infliximab is often considered a… read more here.
Keywords: infliximab; treatment; sarcoidosis; therapy refractory ... See more keywords
Teaching NeuroImages: Sonographic detection of intraneural perineurioma in therapy-refractory carpal tunnel syndrome
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DOI: 10.1212/wnl.0000000000003692
Abstract: A 55-year-old man with typical clinical and electrodiagnostic findings of carpal tunnel syndrome complained of progression of his symptoms. Since repeated surgical interventions did not provide any relief, sonographic examination was performed and depicted a… read more here.
Keywords: carpal tunnel; tunnel syndrome; therapy refractory; nerve ... See more keywords
Targeted Therapy Recommendations for Therapy Refractory Solid Tumors—Data from the Real-World Precision Medicine Platform MONDTI
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DOI: 10.3390/jpm10040188
Abstract: Advanced therapy-refractory solid tumors bear a dismal prognosis and constitute a major challenge in offering effective treatment strategies. In this real-world retrospective analysis of our precision medicine platform MONDTI, we describe the molecular profile of… read more here.
Keywords: medicine; precision medicine; solid tumors; targeted therapy ... See more keywords