MYC and therapy resistance in cancer: risks and opportunities
Sign Up to like & getrecommendations! Published in 2022 at "Molecular Oncology"
DOI: 10.1002/1878-0261.13319
Abstract: The MYC transcription factor, encoded by the c‐MYC proto‐oncogene, is activated by growth‐promoting signals, and is a key regulator of biosynthetic and metabolic pathways driving cell growth and proliferation. These same processes are deregulated in… read more here.
Keywords: myc therapy; resistance cancer; therapy resistance; resistance ... See more keywords
Therapy resistance mechanisms in hematological malignancies
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Cancer"
DOI: 10.1002/ijc.34243
Abstract: Hematologic malignancies are model diseases for understanding neoplastic transformation and serve as prototypes for developing effective therapies. Indeed, the concept of systemic cancer therapy originated in hematologic malignancies and has guided the development of chemotherapy,… read more here.
Keywords: therapy resistance; hematologic malignancies; resistance; treatment ... See more keywords
Three-Dimensional Organoids Reveal Therapy Resistance of Esophageal and Oropharyngeal Squamous Cell Carcinoma Cells
Sign Up to like & getrecommendations! Published in 2019 at "Cellular and Molecular Gastroenterology and Hepatology"
DOI: 10.1016/j.jcmgh.2018.09.003
Abstract: Background & Aims Oropharyngeal and esophageal squamous cell carcinomas, especially the latter, are a lethal disease, featuring intratumoral cancer cell heterogeneity and therapy resistance. To facilitate cancer therapy in personalized medicine, three-dimensional (3D) organoids may… read more here.
Keywords: squamous cell; cancer; therapy; therapy resistance ... See more keywords
Ovarian cancer stem cells more questions than answers.
Sign Up to like & getrecommendations! Published in 2017 at "Seminars in cancer biology"
DOI: 10.1016/j.semcancer.2017.04.009
Abstract: Epithelial ovarian cancer is a highly lethal disease, which is usually diagnosed at a late stage with extensive metastases in the abdominal cavity. Ovarian cancer either develops from the ovarian surface epithelium (OSE) or from… read more here.
Keywords: cancer stem; ovarian cancer; cancer; therapy resistance ... See more keywords
Therapy resistance mediated by cancer stem cells.
Sign Up to like & getrecommendations! Published in 2018 at "Seminars in cancer biology"
DOI: 10.1016/j.semcancer.2018.11.006
Abstract: Cancer stem cells (CSC) possess abilities generally associated with embryonic or adult stem cells, especially self-renewal and differentiation. The CSC model assumes that this subpopulation of cells sustains malignant growth, which suggests a hierarchical organization… read more here.
Keywords: csc; resistance; cancer; therapy resistance ... See more keywords
Hypoxia-induced therapy resistance: Available hypoxia-targeting strategies and current advances in head and neck cancer
Sign Up to like & getrecommendations! Published in 2021 at "Translational Oncology"
DOI: 10.1016/j.tranon.2021.101017
Abstract: Highlights • Hypoxia has long been recognised as a major cause of treatment failure in solid tumour and is a crucial feature of aggressive tumours.• Head and neck cancers have limited treatment options and remain… read more here.
Keywords: resistance available; hypoxia; therapy resistance; induced therapy ... See more keywords
Therapy resistance beyond cellular dormancy
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DOI: 10.1038/s41556-019-0276-7
Abstract: It is commonly accepted that disseminated tumour cells survive cytotoxic chemotherapy because they are not proliferating. A new study now finds that, in contrast to this long-standing concept, both dormant and proliferative cancer cells can… read more here.
Keywords: cellular dormancy; resistance beyond; biology; beyond cellular ... See more keywords
The paradigm of drug resistance in cancer: an epigenetic perspective
Sign Up to like & getrecommendations! Published in 2022 at "Bioscience Reports"
DOI: 10.1042/bsr20211812
Abstract: Abstract Innate and acquired resistance towards the conventional therapeutic regimen imposes a significant challenge for the successful management of cancer for decades. In patients with advanced carcinomas, acquisition of drug resistance often leads to tumor… read more here.
Keywords: resistance cancer; therapy resistance; resistance; cancer ... See more keywords
DDR1 (discoidin domain receptor tyrosine kinase 1) drives glioblastoma therapy resistance by modulating autophagy
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DOI: 10.1080/15548627.2019.1618540
Abstract: ABSTRACT Therapy resistance of tumor cells is a major obstacle for efficient anticancer treatment approaches and has been attributed to tumor heterogeneity as well as genetic and epigenetic changes. Accumulating evidence demonstrates that tumor cell… read more here.
Keywords: kinase; ddr1 discoidin; resistance; receptor ... See more keywords
Obesity enriches for tumor protective microbial metabolites and treatment refractory cells to confer therapy resistance in PDAC
Sign Up to like & getrecommendations! Published in 2022 at "Gut Microbes"
DOI: 10.1080/19490976.2022.2096328
Abstract: ABSTRACT Obesity causes chronic inflammation and changes in gut microbiome. However, how this contributes to poor survival and therapy resistance in patients with pancreatic cancer remain undetermined. Our current study shows that high fat diet-fed… read more here.
Keywords: therapy resistance; pancreatic cancer; control; diet fed ... See more keywords
LDHA and CPT2 association with therapy resistance in prostate cancer
Sign Up to like & getrecommendations! Published in 2021 at "European Journal of Public Health"
DOI: 10.1093/eurpub/ckab120.068
Abstract: The aerobic glycolysis as energy source in cancer confers a selective advantage for its proliferation and survival. Previous in vitro studies demonstrated that treatment with [C16Pyr][Amp], a potential anti-cancer drug in prostate, decreased the transcript… read more here.
Keywords: ldha cpt2; expression; resistance; cancer ... See more keywords