iNKT cells are increased in children with severe therapy-resistant asthma.
Sign Up to like & getrecommendations! Published in 2018 at "Allergologia et immunopathologia"
DOI: 10.1016/j.aller.2017.05.009
Abstract: BACKGROUND Invariant natural killer T (iNKT) cells play complex functions in the immune system, releasing both Th1 and Th2 cytokines. The role of iNKT cells in human asthma is still controversial and never described in… read more here.
Keywords: inkt; severe therapy; therapy resistant; inkt cells ... See more keywords
Zebrafish-Based Screening of Antiseizure Plants Used in Traditional Chinese Medicine: Magnolia officinalis Extract and Its Constituents Magnolol and Honokiol Exhibit Potent Anticonvulsant Activity in a Therapy-Resistant Epilepsy Model.
Sign Up to like & getrecommendations! Published in 2020 at "ACS chemical neuroscience"
DOI: 10.1021/acschemneuro.9b00610
Abstract: With the aim to discover interesting lead compounds that could be further developed into compounds active against pharmacoresistant epilepsies, we first collected 14 medicinal plants used in traditional Chinese medicine (TCM) against epilepsy. Of the… read more here.
Keywords: epilepsy; medicine; antiseizure; therapy resistant ... See more keywords
Targeting therapy-resistant cancer stem cells by hyperthermia
Sign Up to like & getrecommendations! Published in 2017 at "International Journal of Hyperthermia"
DOI: 10.1080/02656736.2017.1279757
Abstract: Abstract Eradication of all malignant cells is the ultimate but challenging goal of anti-cancer treatment; most traditional clinically-available approaches fail because there are cells in a tumour that either escape therapy or become therapy-resistant. A… read more here.
Keywords: cancer stem; therapy; hyperthermia; therapy resistant ... See more keywords
Clinical management of severe therapy-resistant asthma
Sign Up to like & getrecommendations! Published in 2017 at "Expert Review of Respiratory Medicine"
DOI: 10.1080/17476348.2017.1317597
Abstract: ABSTRACT Introduction: Severe therapy-resistant asthma is an area where there has been recent advances in understanding that is percolating into improvements in management. Areas covered: This review covers the recent definition and approach to the… read more here.
Keywords: medicine; severe asthma; severe therapy; therapy resistant ... See more keywords
GP232 Management of seizures in children with therapy-resistant epilepsy
Sign Up to like & getrecommendations! Published in 2019 at "Archives of Disease in Childhood"
DOI: 10.1136/archdischild-2019-epa.291
Abstract: Epilepsies in children represent a heterogeneous group of disorders and syndromes with different etiology, severity, prognosis and treatment. Early diagnosis, accurate recognition of underlying aetiologies leads to more effective management and treatment and improve overall… read more here.
Keywords: seizures children; treatment; gp232 management; therapy resistant ... See more keywords
Therapy-resistant dermatomyositis with extensive ‘lumbar belt’ calcinosis
Sign Up to like & getrecommendations! Published in 2022 at "BMJ Case Reports"
DOI: 10.1136/bcr-2022-249110
Abstract: Calcinosis cutis (CC) is the umbrella term for calcium salt deposition on skin and subcutaneous tissue. We present a unique case of CC associated with anti-Mi2-positive dermatomyositis, having a distinctive distribution of subcutaneous calcifications appearing… read more here.
Keywords: dermatomyositis; calcinosis; therapy resistant; lumbar belt ... See more keywords
Abstract 4051: Combination efficacy of HDAC inhibitor vorinostat and CDK-4/6 dual inhibitor palbociclib against therapy-resistant mantle cell lymphoma
Sign Up to like & getrecommendations! Published in 2017 at "Cancer Research"
DOI: 10.1158/1538-7445.am2017-4051
Abstract: Mantle cell lymphoma (MCL) is an aggressive B-cell lymphoma accounting for about 7% of all non-Hodgkins lymphoma. While multiple therapy regimens are available to treat MCL patients, ultimately relapse from therapy-resistant MCL, making MCL carry… read more here.
Keywords: mcl; combination; inhibitor; therapy resistant ... See more keywords
Abstract 5403: Targeting death-receptors in therapy resistant progressive neuroblastoma: A preliminary insight
Sign Up to like & getrecommendations! Published in 2020 at "Cancer Research"
DOI: 10.1158/1538-7445.am2020-5403
Abstract: Neuroblastoma is the most common cancer in infants and accounts for 9.1% of childhood cancer-related deaths. Despite the current standard of care (SOC), drug-resistant neuroblastoma significantly compromises patient survival. Hence it is critical to identify… read more here.
Keywords: death; targeting death; death receptors; neuroblastoma ... See more keywords
Exploiting allosteric properties of RAF and MEK inhibitors to target therapy-resistant tumors driven by oncogenic BRAF signaling.
Sign Up to like & getrecommendations! Published in 2021 at "Cancer discovery"
DOI: 10.1158/2159-8290.cd-20-1351
Abstract: Current clinical RAF inhibitors (RAFi) inhibit monomeric BRAF (mBRAF), but are less potent against dimeric BRAF (dBRAF). RAFi equipotent for mBRAF and dBRAF have been developed, but are predicted to have lower therapeutic index. Here… read more here.
Keywords: therapy resistant; properties raf; braf; raf mek ... See more keywords
Impact of Omalizumab in Children From a Middle-Income Country With Severe Therapy-Resistant Asthma: A Real Life Study
Sign Up to like & getrecommendations! Published in 2018 at "Pediatrics"
DOI: 10.1542/peds.2018-2420rrrr
Abstract: PM Pitrez, RG de Souza, C Roncada. Pediatr Pulmonol. 2017;52(11):1408–1413 In this study, the authors examined the health care effects associated with the use of omalizumab for severe childhood asthma in low- and middle-income countries… read more here.
Keywords: middle income; severe therapy; therapy resistant; study ... See more keywords
Therapy Resistant Gastroenteropancreatic Neuroendocrine Tumors
Sign Up to like & getrecommendations! Published in 2022 at "Cancers"
DOI: 10.3390/cancers14194769
Abstract: Simple Summary The medical care for patients with neuroendocrine tumors arising from the intestines, pancreas, or stomach is frequently limited by the development resistance to common treatment approaches including targeted therapies and chemotherapy. The purpose… read more here.
Keywords: development; neuroendocrine tumors; resistance; gastroenteropancreatic neuroendocrine ... See more keywords