The use of molecular volumetric parameters for the evaluation of Lu-177 PSMA I&T therapy response and survival
Sign Up to like & getrecommendations! Published in 2019 at "Annals of Nuclear Medicine"
DOI: 10.1007/s12149-019-01376-3
Abstract: The primary aim of this study was to evaluate the volumetric therapy response via Ga-68 PSMA I&T PET/CT in patients treated with Lu-177 PSMA I&T therapy. The secondary purpose was to determine the impact of… read more here.
Keywords: response; therapy response; 177 psma; therapy ... See more keywords
Molecular Imaging and Precision Medicine: PET/Computed Tomography and Therapy Response Assessment in Oncology.
Sign Up to like & getrecommendations! Published in 2017 at "PET clinics"
DOI: 10.1016/j.cpet.2016.08.002
Abstract: A variety of methods have been developed to assess tumor response to therapy. Standardized qualitative criteria based on 18F-fluoro-deoxyglucose PET/computed tomography have been proposed to evaluate the treatment effectiveness in specific cancers and these allow… read more here.
Keywords: medicine; oncology; therapy response; response assessment ... See more keywords
Genomic determinants of therapy response in ETV6::RUNX1 leukemia
Sign Up to like & getrecommendations! Published in 2025 at "Leukemia"
DOI: 10.1038/s41375-025-02683-7
Abstract: ETV6::RUNX1 leukemia is the second most common subtype of childhood B cell acute lymphoblastic leukemia (B-ALL). Although it generally has a low relapse risk, a significant proportion of B-ALL relapses occur within this subtype due… read more here.
Keywords: therapy response; etv6 runx1; response; runx1 leukemia ... See more keywords
Predicting BRCA mutation and stratifying targeted therapy response using multimodal learning: a multicenter study
Sign Up to like & getrecommendations! Published in 2024 at "Annals of Medicine"
DOI: 10.1080/07853890.2024.2399759
Abstract: Abstract Background The status of BRCA1/2 genes plays a crucial role in the treatment decision-making process for multiple cancer types. However, due to high costs and limited resources, a demand for BRCA1/2 genetic testing among… read more here.
Keywords: model; status; therapy response; study ... See more keywords
Bladder cancer organoids as a functional system to model different disease stages and therapy response
Sign Up to like & getrecommendations! Published in 2022 at "Nature Communications"
DOI: 10.1101/2022.03.31.486514
Abstract: Bladder Cancer (BLCa) inter-patient heterogeneity is the primary cause of treatment failure, suggesting that patients could benefit from a more personalized treatment approach. Patient-derived organoids (PDOs) have been successfully used as a functional model for… read more here.
Keywords: drug; bladder cancer; response; therapy response ... See more keywords
Cancer organoids to model therapy response
Sign Up to like & getrecommendations! Published in 2018 at "Science"
DOI: 10.1126/science.359.6378.880-d
Abstract: Organoids Cancer organoids are miniature, three-dimensional cell culture models that can be made from primary patient tumors and studied in the laboratory. Vlachogiannis et al. asked whether such “tumor-in-a-dish” approaches can be used to predict… read more here.
Keywords: drug; therapy response; cancer organoids; model therapy ... See more keywords
Abstract 7612: Genetic predictors of anti-PD(L)-1 therapy response in hepatocellular carcinoma
Sign Up to like & getrecommendations! Published in 2024 at "Cancer Research"
DOI: 10.1158/1538-7445.am2024-7612
Abstract: Introduction: Immunotherapy targeting PD-1/PD-L1 shows promise in treating hepatocellular carcinoma (HCC), but standard predictors like PD-L1 expression are unreliable for gauging treatment response. RNA sequencing has identified a BMS 4-gene inflammatory signature that could more… read more here.
Keywords: therapy response; anti therapy; hepatocellular carcinoma; therapy ... See more keywords
Abstract IA07: Genetic determinants of tumor development, therapy response and resistance in mouse models of BRCA-deficient breast cancer
Sign Up to like & getrecommendations! Published in 2017 at "Molecular Cancer Research"
DOI: 10.1158/1557-3125.dnarepair16-ia07
Abstract: Heterozygous germline mutations in BRCA1 or BRCA2 strongly predispose to development of breast and ovarian cancer (as well as other cancer types) via loss of the remaining wildtype allele. BRCA1/2-deficient cancers are defective in DNA… read more here.
Keywords: breast; therapy response; resistance; cancer ... See more keywords
Therapy Response and Outcome Explained by Leukemia Cell of Origin.
Sign Up to like & getrecommendations! Published in 2020 at "Cancer discovery"
DOI: 10.1158/2159-8290.cd-20-1080
Abstract: In this issue of Cancer Discovery, Cai and colleagues delineate a new mechanism that links cell of origin, the transcription factor EVI1, apoptotic priming, and therapeutic susceptibility in mixed lineage leukemia-rearranged acute myeloid leukemia. These… read more here.
Keywords: cell origin; leukemia; outcome explained; therapy response ... See more keywords
Does side matter? Deciphering mechanisms that underpin side-dependent pathogenesis and therapy response in colorectal cancer
Sign Up to like & getrecommendations! Published in 2025 at "Molecular Cancer"
DOI: 10.1186/s12943-025-02327-5
Abstract: Colorectal cancer (CRC) is stratified by heterogeneity between disease sites, with proximal right-sided CRC (RCRC) multifactorial in its distinction from distal left-sided CRC (LCRC). Notably, right-sided tumors are associated with aggressive disease characteristics which culminate… read more here.
Keywords: colorectal cancer; cancer; cancer side; side ... See more keywords
Prediction of radiation therapy response in breast cancer patients.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2017.35.15_suppl.565
Abstract: 565Background: While radiation portals are tailored to a patient’s unique anatomy and the selection of systemic agents routinely employs biomarker data, the selection of radiotherapy based on a pat... read more here.
Keywords: radiation therapy; prediction radiation; breast cancer; therapy response ... See more keywords