Biochemical characterization and mutational studies of the 8-oxoguanine DNA glycosylase from the hyperthermophilic and radioresistant archaeon Thermococcus gammatolerans
Sign Up to like & getrecommendations! Published in 2019 at "Applied Microbiology and Biotechnology"
DOI: 10.1007/s00253-019-10031-w
Abstract: 8-oxoguanine (GO) is a major lesion found in DNA that arises from guanine oxidation. The hyperthermophilic and radioresistant euryarchaeon Thermococcus gammatolerans encodes an archaeal GO DNA glycosylase (Tg-AGOG). Here, we characterized biochemically Tg-AGOG and probed… read more here.
Keywords: dna; dna glycosylase; mutational studies; hyperthermophilic radioresistant ... See more keywords
Biochemical characterization and mutational studies of a novel 3-methlyadenine DNA glycosylase II from the hyperthermophilic Thermococcus gammatolerans.
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DOI: 10.1016/j.dnarep.2020.103030
Abstract: The hyperthermophilic and radioresistant euryarchaeon Thermococcus gammatolerans encodes a putative 3-methlyadenine DNA glycosylase II (Tg-AlkA). Herein, we report biochemical characterization and catalytic mechanism of Tg-AlkA. The recombinant Tg-AlkA can excise hypoxanthine (Hx) and 1-methlyadenine (1-meA)… read more here.
Keywords: dna; dna glycosylase; thermococcus; thermococcus gammatolerans ... See more keywords
Biochemical and functional characterization of a thermostable RecJ exonuclease from Thermococcus gammatolerans.
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DOI: 10.1016/j.ijbiomac.2022.02.033
Abstract: RecJ is ubiquitous in bacteria and Archaea, and play an important role in DNA replication and repair. Currently, our understanding on biochemical function of archaeal RecJ is incomplete due to limited reports. The genome of… read more here.
Keywords: tga recj; exonuclease; recj; thermococcus gammatolerans ... See more keywords