Thermodynamic consequences of Tyr to Trp mutations in the cation–π-mediated binding of trimethyllysine by the HP1 chromodomain†
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DOI: 10.1039/d0sc00227e
Abstract: Evolution has converged on cation–π interactions for recognition of quaternary alkyl ammonium groups such as trimethyllysine (Kme3). While computational modelling indicates that Trp provides the strongest cation–π interaction of the native aromatic amino acids, there… read more here.
Keywords: cation interaction; cation; thermodynamic consequences; hp1 chromodomain ... See more keywords