Thermodynamic Constraints Improve Metabolic Networks.
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DOI: 10.1016/j.bpj.2017.06.018
Abstract: In pursuit of establishing a realistic metabolic phenotypic space, the reversibility of reactions is thermodynamically constrained in modern metabolic networks. The reversibility constraints follow from heuristic thermodynamic poise approximations that take anticipated cellular metabolite concentration… read more here.
Keywords: reversibility constraints; reversibility; network; reconciliation ... See more keywords
Beyond Thermodynamic Constraints: Evolutionary Sampling Generates Realistic Protein Sequence Variation
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DOI: 10.1534/genetics.118.300699
Abstract: The computational design of protein sequences has yielded major successes in several application areas. However, when the principles of protein design are applied to molecular evolution, results tend to be poor... Biological evolution generates a… read more here.
Keywords: protein; variation; protein sequences; thermodynamic constraints ... See more keywords