Contra-thermodynamic halolactonization of lactam-tethered 5-aryl-4(E)-pentenoic acids for the flexible and stereocontrolled synthesis of fused lactam-halolactones
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DOI: 10.1039/d2ra04177d
Abstract: Halolactonization of alkenoic acids enables the construction of oxygen-heterocycles via intramolecular halonium-induced nucleophilic addition. Although the literature is currently inundated with halolactonizations of 5-aryl-4(E)-pentenoic acids that predictably afford the 6-endo cyclization adducts, methods that reliably… read more here.
Keywords: aryl pentenoic; halolactonization lactam; contra thermodynamic; thermodynamic halolactonization ... See more keywords