An environmentally benign HPLC-UV method for thermodynamic solubility measurement of vitamin D3 in various (Transcutol + water) mixtures
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Molecular Liquids"
DOI: 10.1016/j.molliq.2017.07.011
Abstract: Abstract In the current research work, an environmentally benign “reversed phase high-performance liquid chromatography (RP-HPLC)” method was developed and validated for thermodynamic solubility measurement of vitamin D3 in various [2-(2-ethoxyethoxy)ethanol (Transcutol®) + water] mixtures. The HPLC analysis… read more here.
Keywords: transcutol water; thermodynamic solubility; solubility; hplc method ... See more keywords
A New Method of Constructing a Drug-Polymer Temperature-Composition Phase Diagram Using Hot-Melt Extrusion.
Sign Up to like & getrecommendations! Published in 2018 at "Molecular pharmaceutics"
DOI: 10.1021/acs.molpharmaceut.7b00445
Abstract: Current experimental methodologies used to determine the thermodynamic solubility of an API within a polymer typically involves establishing the dissolution/melting end point of the crystalline API within a physical mixture or through the use of… read more here.
Keywords: temperature; drug polymer; thermodynamic solubility; drug ... See more keywords