Human RSPO1 Mutation Represses Beige Adipocyte Thermogenesis and Contributes to Diet‐Induced Adiposity (Adv. Sci. 12/2023)
Sign Up to like & getrecommendations! Published in 2023 at "Advanced Science"
DOI: 10.1002/advs.202207152
Abstract: Recent genetic evidence has linked WNT downstream mutations to fat distribution. However, the roles of WNTs in human obesity remain unclear. Here, the authors screen all Wnt‐related paracrine factors in 1994 obese cases and 2161… read more here.
Keywords: rspo1; induced adiposity; mutation; thermogenesis ... See more keywords
Peripheral thyroid hormone deiodination: Entry points to elucidate mechanisms of metabolic adaptation during weight regain
Sign Up to like & getrecommendations! Published in 2023 at "Obesity"
DOI: 10.1002/oby.23721
Abstract: The concept of dual‐adaptive thermogenesis underlying metabolic adaptation to prolonged energy deficit posits that there are two control systems that govern energy sparing: a rapid‐reacting system to energy deficit and a slow‐reacting system to fat… read more here.
Keywords: weight regain; metabolic adaptation; thyroid; entry points ... See more keywords
Rutin‐activated adipose tissue thermogenesis is correlated with increased intestinal short‐chain fatty acid levels
Sign Up to like & getrecommendations! Published in 2022 at "Phytotherapy Research"
DOI: 10.1002/ptr.7462
Abstract: The activation of thermogenic programs in brown adipose tissue (BAT) and white adipose tissue (WAT) provides a promising approach to increasing energy expenditure during obesity and diabetes treatment. Although evidence has been found that rutin… read more here.
Keywords: adipose tissue; bat; thermogenesis; rutin ... See more keywords
Translational Pharmacology and Physiology of Brown Adipose Tissue in Human Disease and Treatment.
Sign Up to like & getrecommendations! Published in 2019 at "Handbook of experimental pharmacology"
DOI: 10.1007/164_2018_184
Abstract: Human brown adipose tissue (BAT) is experimentally modeled to better understand the biology of this important metabolic tissue, and also to enable the potential discovery and development of novel therapeutics for obesity and sequelae resulting… read more here.
Keywords: energy; bat; pharmacology; physiology ... See more keywords
Estradiol Regulation of Brown Adipose Tissue Thermogenesis.
Sign Up to like & getrecommendations! Published in 2017 at "Advances in experimental medicine and biology"
DOI: 10.1007/978-3-319-70178-3_15
Abstract: Physiologically, estrogens carry out a myriad of functions, the most essential being the regulation of the reproductive axis. Currently, it is also dogmatic that estrogens play an important role modulating energy balance and metabolism. In… read more here.
Keywords: energy; adipose tissue; regulation; thermogenesis ... See more keywords
Multiorgan contribution to non-shivering and shivering thermogenesis and vascular responses during gradual cold exposure in humans.
Sign Up to like & getrecommendations! Published in 2020 at "European journal of applied physiology"
DOI: 10.1007/s00421-020-04496-1
Abstract: PURPOSE Human brown adipose tissue (BAT) is known to be a significant thermoeffector in non-shivering thermogenesis (NST), albeit with individual variations in the BAT activity. We hypothesized that humans with less BAT would have more… read more here.
Keywords: volume; non shivering; bat volume; bat ... See more keywords
Temporal specificity of IL-6 knockout in enhancing the thermogenic capability of brown adipose tissue.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of physiology and biochemistry"
DOI: 10.1007/s13105-021-00847-4
Abstract: Although interleukin-6 (IL-6) has been regarded as a homeostatic regulator of fat metabolism, its role in brown adipose thermogenesis remains to be further clarified. By using wild-type (WT) and IL-6-knockout (KO) mice, this study aims… read more here.
Keywords: thermogenic capability; capability brown; adipose tissue; brown adipose ... See more keywords
Origins and early development of the concept that brown adipose tissue thermogenesis is linked to energy balance and obesity.
Sign Up to like & getrecommendations! Published in 2017 at "Biochimie"
DOI: 10.1016/j.biochi.2016.09.007
Abstract: Brown adipose tissue (BAT) was identified as a thermogenic organ in 1961, and in 1978 shown to be the major site of thermoregulatory non-shivering thermogenesis in rats acclimated to the cold. Investigations in the mid-late… read more here.
Keywords: bat; tissue; adipose tissue; obesity ... See more keywords
Secretin-Activated Brown Fat Mediates Prandial Thermogenesis to Induce Satiation
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DOI: 10.1016/j.cell.2018.10.016
Abstract: The molecular mediator and functional significance of meal-associated brown fat (BAT) thermogenesis remains elusive. Here, we identified the gut hormone secretin as a non-sympathetic BAT activator mediating prandial thermogenesis, which consequentially induces satiation, thereby establishing… read more here.
Keywords: prandial thermogenesis; brown fat; bat; satiation ... See more keywords
miRNA-32 Drives Brown Fat Thermogenesis and Trans-activates Subcutaneous White Fat Browning in Mice
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DOI: 10.1016/j.celrep.2017.04.035
Abstract: SUMMARY Brown adipose tissue (BAT) activation and subcutaneous white fat browning are essential components of the thermogenic response to cold stimulus in mammals. microRNAs have been shown to regulate both processes in cis. Here, we… read more here.
Keywords: white fat; fat browning; bat; thermogenesis ... See more keywords
Single-Cell RNA Profiling Reveals Adipocyte to Macrophage Signaling Sufficient to Enhance Thermogenesis
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DOI: 10.1016/j.celrep.2020.107998
Abstract: SUMMARY Adipocytes deficient in fatty acid synthase (iAdFASNKO) emit signals that mimic cold exposure to enhance the appearance of thermogenic beige adipocytes in mouse inguinal white adipose tissues (iWATs). Both cold exposure and iAdFASNKO upregulate… read more here.
Keywords: single cell; cell; iadfasnko mice; enhance ... See more keywords