Thermoneutral housing exacerbates non-alcoholic fatty liver disease in mice and allows for sex-independent disease modeling
Sign Up to like & getrecommendations! Published in 2017 at "Nature medicine"
DOI: 10.1038/nm.4346
Abstract: Nonalcoholic fatty liver disease (NAFLD), a common prelude to cirrhosis and hepatocellular carcinoma, is the most common chronic liver disease worldwide. Defining the molecular mechanisms underlying the pathogenesis of NAFLD has been hampered by a… read more here.
Keywords: fatty liver; disease; thermoneutral housing; housing ... See more keywords
Thermoneutral housing shapes hepatic inflammation and damage in mouse models of non-alcoholic fatty liver disease
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2023.1095132
Abstract: Introduction Inflammation is a common unifying factor in experimental models of non-alcoholic fatty liver disease (NAFLD) progression. Recent evidence suggests that housing temperature-driven alterations in hepatic inflammation correlate with exacerbated hepatic steatosis, development of hepatic… read more here.
Keywords: inflammation; damage; immune cell; hepatic inflammation ... See more keywords