A combination drug delivery system employing thermosensitive liposomes for enhanced cell penetration and improved in vitro efficacy.
Sign Up to like & getrecommendations! Published in 2019 at "International journal of pharmaceutics"
DOI: 10.1016/j.ijpharm.2019.118912
Abstract: Drug-loaded thermosensitive liposomes are investigated as drug delivery systems in combination with local mild hyperthermia therapy due to their capacity to release their cargo at a specific temperature range (40-42 °C). Additional benefit can be… read more here.
Keywords: drug delivery; drug; cell penetration; thermosensitive liposomes ... See more keywords
Inhomogeneous crystal grain formation in DPPC‐DSPC based thermosensitive liposomes determines content release kinetics
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Controlled Release"
DOI: 10.1016/j.jconrel.2016.12.030
Abstract: ABSTRACT Thermosensitive liposomes (TSL) receive attention due to their rapid externally controlled drug release at transition temperature in combination with hyperthermia. This rapid release feature of TSL occurs when the liposome membrane is going through… read more here.
Keywords: dppc dspc; content release; thermosensitive liposomes; release ... See more keywords
Preparation and characterization of gadolinium-based thermosensitive liposomes: A potential nanosystem for selective drug delivery to cancer cells
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Drug Delivery Science and Technology"
DOI: 10.1016/j.jddst.2021.102686
Abstract: Abstract Gadodiamide (Gd-DTPA-BMA) is a gadolinium-based complex, used as a contrast agent in magnetic resonance imaging procedures. Recent studies revealed the capacity of this complex of inducing apoptosis in neoplastic cells. However, a great challenge… read more here.
Keywords: dtpa bma; thermosensitive liposomes; drug; cancer ... See more keywords
Thermosensitive Liposomes Encapsulating Nedaplatin and Picoplatin Demonstrate Enhanced Cytotoxicity against Breast Cancer Cells
Sign Up to like & getrecommendations! Published in 2022 at "ACS Omega"
DOI: 10.1021/acsomega.2c04525
Abstract: Thermosensitive liposomes (TSL) have been used for localized temperature-responsive release of chemotherapeutics into solid cancers, with a minimum of one invention currently in clinical trials (phase III). In this study, TSL was designed using a… read more here.
Keywords: breast; picoplatin; tsl; release ... See more keywords
Stepwise photothermal therapy and chemotherapy by composite scaffolds of gold nanoparticles, BP nanosheets and gelatin immobilized with doxorubicin-loaded thermosensitive liposomes.
Sign Up to like & getrecommendations! Published in 2022 at "Biomaterials science"
DOI: 10.1039/d2bm01155g
Abstract: In recent years, the synergistic effect of photothermal therapy (PTT) and chemotherapy has been recognized as an effective strategy for cancer treatment. Controlling the PTT temperature and drug release profile is desirable for minimizing the… read more here.
Keywords: photothermal therapy; effect; composite scaffolds; ptt chemotherapy ... See more keywords
A pilot trial of doxorubicin containing phosphatidyldiglycerol based thermosensitive liposomes in spontaneous feline soft tissue sarcoma
Sign Up to like & getrecommendations! Published in 2017 at "International Journal of Hyperthermia"
DOI: 10.1080/02656736.2016.1230233
Abstract: Abstract Purpose: Doxorubicin (DOX)-loaded phosphatidyldiglycerol-based thermosensitive liposomes (DPPG2-TSL-DOX) combined with local hyperthermia (HT) was evaluated in cats with locally advanced spontaneous fibrosarcomas (soft tissue sarcoma [STS]). The study was designed to evaluate the safety and… read more here.
Keywords: tissue sarcoma; based thermosensitive; soft tissue; phosphatidyldiglycerol based ... See more keywords
Selecting ideal drugs for encapsulation in thermosensitive liposomes and other triggered nanoparticles
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Hyperthermia"
DOI: 10.1080/02656736.2022.2086303
Abstract: Abstract Objective Thermosensitive liposomes (TSL) and other triggered drug delivery systems (DDS) are promising therapeutic strategies for targeted drug delivery. However, successful designs with candidate drugs depend on many variables, including nanoparticle formulation, drug properties,… read more here.
Keywords: cell; thermosensitive liposomes; cell uptake; computer model ... See more keywords
In vitro and in vivo activity of thermosensitive liposomes loaded with doxorubicin and cisplatin
Sign Up to like & getrecommendations! Published in 2022 at "Drug Development and Industrial Pharmacy"
DOI: 10.1080/03639045.2022.2102648
Abstract: Abstract Thermosensitive liposomes loaded with cisplatin and doxorubicin composed of DPPC, DSPC, and DPPE-PEG5000 with different ratios were prepared by thin film hydration method. The Differential Scanning Calorimetry (DSC) curves showed that the liposomes composed… read more here.
Keywords: doxorubicin cisplatin; results showed; doxorubicin; thermosensitive liposomes ... See more keywords
Preparation and in vitro evaluation of thermosensitive liposomes targeting for ovarian cancer.
Sign Up to like & getrecommendations! Published in 2022 at "Current drug delivery"
DOI: 10.2174/1567201819666220321110812
Abstract: INTRODUCTION Liposomes have been widely used in drug delivery systems because the encapsulation of liposomes changes the biological distribution profile and improves the therapeutic indices of various drugs. Thermosensitive liposomes have been proven to be… read more here.
Keywords: cancer; targeting ovarian; liposomes targeting; thermosensitive liposomes ... See more keywords
Review of the Delivery Kinetics of Thermosensitive Liposomes
Sign Up to like & getrecommendations! Published in 2023 at "Cancers"
DOI: 10.3390/cancers15020398
Abstract: Simple Summary Various nanoparticles have been developed over the last few decades for targeted drug delivery to cancerous tumors while reducing toxicities. Thermosensitive liposomes (TSL) belong to the category of triggered nanoparticle delivery systems, where… read more here.
Keywords: thermosensitive liposomes; hyperthermia; tsl; drug delivery ... See more keywords
Pharmaceutical Development and Design of Thermosensitive Liposomes Based on the QbD Approach
Sign Up to like & getrecommendations! Published in 2022 at "Molecules"
DOI: 10.3390/molecules27051536
Abstract: This study aimed to produce thermosensitive liposomes (TSL) by applying the quality by design (QbD) concept. In this paper, our research group collected and studied the parameters that significantly impact the quality of the liposomal… read more here.
Keywords: design thermosensitive; pharmaceutical development; development design; design ... See more keywords