PhI-Catalyzed Intramolecular Oxidative Coupling Toward Synthesis of 2-Amino-1,3,4-Thiadizoles
Sign Up to like & getrecommendations! Published in 2018 at "Catalysis Letters"
DOI: 10.1007/s10562-018-2541-y
Abstract: AbstractA highly efficient method for the synthesis of thiadiazole derivatives via intramolecular oxidative coupling of thiosemicarbazide, using the in situ generated hypervalent iodine(III) reagents is developed. The protocol can be carried out smoothly and provides… read more here.
Keywords: phi catalyzed; intramolecular oxidative; oxidative coupling; thiadiazole derivatives ... See more keywords
Effects of some 5-anilino-1,2,4-thiadiazole derivatives onto leukemic cells
Sign Up to like & getrecommendations! Published in 2017 at "Russian Chemical Bulletin"
DOI: 10.1007/s11172-017-1833-5
Abstract: The antileukemic activities of some thiadiazole derivatives in the forms of hydrochlorides and salicylates have been determined. The insertion of salicylate ion in the compound increases the therapeutic index, mainly due to the reduction of… read more here.
Keywords: derivatives onto; leukemic cells; effects anilino; anilino thiadiazole ... See more keywords
Synthesis and antitubercular evaluation of imidazo[2,1-b][1,3,4]thiadiazole derivatives
Sign Up to like & getrecommendations! Published in 2017 at "Arabian Journal of Chemistry"
DOI: 10.1016/j.arabjc.2013.01.001
Abstract: Abstract In the present study, a series of imidazo[2,1-b][1,3,4]thiadiazole derivatives 5(a–j) were synthesized and characterized by IR, 1H NMR, 13C NMR and mass spectral technique. The compounds were evaluated for their in vitro antitubercular activity… read more here.
Keywords: imidazo thiadiazole; antitubercular evaluation; synthesis antitubercular; thiadiazole derivatives ... See more keywords
Conjugates of tacrine and 1,2,4-thiadiazole derivatives as new potential multifunctional agents for Alzheimer's disease treatment: Synthesis, quantum-chemical characterization, molecular docking, and biological evaluation.
Sign Up to like & getrecommendations! Published in 2019 at "Bioorganic chemistry"
DOI: 10.1016/j.bioorg.2019.103387
Abstract: We synthesized conjugates of tacrine with 1,2,4-thiadiazole derivatives linked by two different spacers, pentylaminopropene (compounds 4) and pentylaminopropane (compounds 5), as potential drugs for the treatment of Alzheimer's disease (AD). The conjugates effectively inhibited cholinesterases… read more here.
Keywords: alzheimer disease; treatment; tacrine thiadiazole; thiadiazole derivatives ... See more keywords
Discovery of [1,2,4]triazolo[3,4-b][1,3,4]thiadiazole derivatives as novel, potent and selective c-Met kinase inhibitors: Synthesis, SAR study, and biological activity.
Sign Up to like & getrecommendations! Published in 2018 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2018.03.049
Abstract: A series of [1,2,4]triazolo[3,4-b][1,3,4]thiadiazole derivatives were designed, synthesized and evaluated for their biological activity. Most of these compounds showed potent activities against c-Met kinase and cell growth inhibition. The most promising compound, 7d, has the… read more here.
Keywords: biological activity; met kinase; triazolo thiadiazole; thiadiazole derivatives ... See more keywords
Straightforward synthesis of novel substituted 1,3,4-thiadiazole derivatives in choline chloride-based deep eutectic solvent
Sign Up to like & getrecommendations! Published in 2017 at "Tetrahedron Letters"
DOI: 10.1016/j.tetlet.2017.01.057
Abstract: A one-pot, three-component route for the synthesis of novel 1,3,4-thiadiazole derivatives using a ketene S,S-acetal, a carbonyl compound and thiocarbohydrazide is described. The main advantages of this approach are high yields, short reaction times, simple… read more here.
Keywords: synthesis novel; straightforward synthesis; novel substituted; substituted thiadiazole ... See more keywords
Structural and Energetic Properties of Weak Noncovalent Interactions in Two Closely Related 3,6-Disubstituted-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole Derivatives: In Vitro Cyclooxygenase Activity, Crystallography, and Computational Investigations
Sign Up to like & getrecommendations! Published in 2022 at "ACS Omega"
DOI: 10.1021/acsomega.2c04252
Abstract: Two 3,6-disubstituted-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole derivatives, namely, 3-(adamantan-1-yl)-6-(2-chloro-6-fluorophenyl)-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole 1 and 6-(2-chloro-6-fluorophenyl)-3-phenyl-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole 2, were prepared, and the detailed analysis of the weak intermolecular interactions responsible for the supramolecular self-assembly was performed using X-ray diffraction and theoretical tools. Analyses of… read more here.
Keywords: triazolo thiadiazole; energetic properties; structural energetic; thiadiazole derivatives ... See more keywords
Electrochemical study of 2-amino-5-mercapto-1,3,4-thiadiazole in the absence and presence of p-benzoquinone: an efficient strategy for the electrosynthesis of new 1,3,4-thiadiazole derivatives
Sign Up to like & getrecommendations! Published in 2023 at "RSC Advances"
DOI: 10.1039/d2ra07250e
Abstract: In this study, first, the electrochemical behavior of 2-amino-5-mercapto-1,3,4-thiadiazole (AMT) was fully investigated in the absence and presence of electrochemically generated p-benzoquinone (p-BQ, which is the oxidized form of hydroquinone), as an electrophile, via cyclic… read more here.
Keywords: new thiadiazole; electrosynthesis new; absence presence; mercapto thiadiazole ... See more keywords
An efficient synthesis and antimicrobial activity of N-bridged triazolo[3,4-b]thiadiazine and triazolo[3,4-b]thiadiazole derivatives under microwave irradiation
Sign Up to like & getrecommendations! Published in 2020 at "Synthetic Communications"
DOI: 10.1080/00397911.2020.1726397
Abstract: Abstract Microwave synthesis for a new series of triazolo[3,4-b]thiadiazines and triazolo[3,4-b]thiadiazoles was described. Thus, intermolecular cyclization of triazole 1 with ethyl bromoacetate, chloroacetyl chloride or different α-bromoketones under both conventional and microwave conditions afforded triazolo[3,4-b]thiadiazine… read more here.
Keywords: triazolo; triazolo thiadiazole; thiadiazole derivatives; thiadiazine triazolo ... See more keywords
Crystal structure and Hirshfeld surface analysis of two organic salts based on 1,3,4-thiadiazole derivatives
Sign Up to like & getrecommendations! Published in 2023 at "Acta Crystallographica Section E: Crystallographic Communications"
DOI: 10.1107/s2056989022012154
Abstract: Two organic salts based on 1,3,4 thiadiazole derivatives have been obtained and their structures have been established by single-crystal X-ray analysis. read more here.
Keywords: salts based; organic salts; based thiadiazole; analysis ... See more keywords
Discovery of Novel 2-Amino-5-(Substituted)-1,3,4-Thiadiazole Derivatives: New Utilities for Colon Cancer Treatment.
Sign Up to like & getrecommendations! Published in 2018 at "Anti-cancer agents in medicinal chemistry"
DOI: 10.2174/1871520617666170419122916
Abstract: BACKGROUND Colon cancer is one of the most widespread disease, the mortality rate is high due to cancer metastasis and the development of drug resistance. In this regards, new chemotherapeutic agents with specific mechanisms of… read more here.
Keywords: cancer; vr24 vr27; thiadiazole derivatives; colon cancer ... See more keywords