Synthesis of imidazo-thiadiazole linked indolinone conjugates and evaluated their microtubule network disrupting and apoptosis inducing ability.
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DOI: 10.1016/j.bioorg.2017.11.021
Abstract: A series of imidazo[2,1-b][1,3,4]thiadiazole linked indolinone conjugates were synthesized and investigated for antiproliferative activity in different human cancer cell lines by changing various substitutions at indolinone and phenyl ring systems. Among them conjugates 7, 14… read more here.
Keywords: imidazo thiadiazole; microtubule network; apoptosis; linked indolinone ... See more keywords