Thiophene ring-opening reactions. Direct access to the synthesis of 1,3,4-thiadiazoline-(condenced) pyridone hybrids
Sign Up to like & getrecommendations! Published in 2021 at "Tetrahedron"
DOI: 10.1016/j.tet.2021.131957
Abstract: Abstract The reaction of N’-(aryl)benzothiohydrazides with 2-chloro-7-cyclopropyl-3-nitro-4-oxothieno[2,3-b]pyridine-5-carboxylic ester/acid in the presence of triethylamine furnished, upon addition of iodomethane, the respective 1,3,4-thiadiazoline-(6-methylthio-4-oxopyridine) hybrids. Interestingly, the reaction of thiohydrazides with 4-oxothieno[2,3-b]pyridines incorporating N1-(2’-halogeno-5’-nitrophenyl) entities generated 1,3-thiazoline ring… read more here.
Keywords: opening reactions; thiadiazoline; thiophene ring; direct access ... See more keywords